ID   A0A3Q3W7N8_MOLML        Unreviewed;       648 AA.
AC   A0A3Q3W7N8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=T-box domain-containing protein {ECO:0000259|PROSITE:PS50252};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000012536.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000012536.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00201}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR   AlphaFoldDB; A0A3Q3W7N8; -.
DR   Ensembl; ENSMMOT00000012741.1; ENSMMOP00000012536.1; ENSMMOG00000009639.1.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd20188; T-box_TBX2_3-like; 1.
DR   Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR022582; TBX2/3_TAD.
DR   InterPro; IPR048387; TBX2_3_RD.
DR   InterPro; IPR002070; TF_Brachyury.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11267:SF91; T-BOX TRANSCRIPTION FACTOR TBX3; 1.
DR   Pfam; PF00907; T-box; 1.
DR   Pfam; PF12598; TBX; 1.
DR   Pfam; PF20627; TBX2-3_RD; 1.
DR   PRINTS; PR00938; BRACHYURY.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00201};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          104..282
FT                   /note="T-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50252"
FT   REGION          301..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..439
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  71677 MW;  121AAE4AAA11FA65 CRC64;
     MRDPVIQGSS MAYHPFIPHR GPEFAMSAML GHQPPFFPAL ALPHSGSLSL PGALGKPIMD
     QLMGAAETGL HFSSLGHQAA AAHLRPLKTL EPEEEVEDDP KVHLEAKELW ELFHKRGTEM
     VITKSGRRMF PPFKVRCTGL DKKAKYILLM DIVAADDCRY KFHNSRWMVA GKADPEMPKR
     MYIHPDSPAT GEQWMSKVVN FHKLKLTNNI SDKHGFTILN SMHKYQPRFH IVRANDILKL
     PYSTFRTYVF PETDFIAVTA YQNDKITQLK IDHNPFAKGF RDTGNGRREK RKQLALQSIR
     SYEEQQKKEN GGSDDSSGEQ PAFKCFGQAS PAVSTVGPPH LKDYCDSDED SDDESKDGQL
     KDGPDSSKIS TTTEDGKDHE ASPAKGHPFP NSDASSRTEK SHADSRQSPI TVISSTTRSG
     EDLKSPSLEP PKTDDCRPAS KDTFVPLTVQ TDGPHIGHGH LHNFGFPTGL TGQQFFNHLG
     SAHPFLLHPS QFNVGGAFSN MAAGMGPLLA AVSTGGVSSM DTASMASAPQ TLTGAPGLPF
     HLQQHVLASQ LSFGLCCIGA MSSLQHRHRV LESFNKILKY HLVSDTFLTT KLWPSTVFLF
     VSGNNFHLSR DIYLSPIRRK RQSQSFRALD STPGISTWDS NLDKRRAL
//