ID   A0A3Q3W935_MOLML        Unreviewed;       734 AA.
AC   A0A3Q3W935;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Exostosin glycosyltransferase 1 {ECO:0008006|Google:ProtNLM};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000010933.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000010933.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC       {ECO:0000256|ARBA:ARBA00010271}.
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DR   AlphaFoldDB; A0A3Q3W935; -.
DR   Ensembl; ENSMMOT00000011121.1; ENSMMOP00000010933.1; ENSMMOG00000008319.1.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR004263; Exostosin.
DR   InterPro; IPR040911; Exostosin_GT47.
DR   InterPro; IPR015338; GT64.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR   PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR   Pfam; PF03016; Exostosin; 1.
DR   Pfam; PF09258; Glyco_transf_64; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          82..367
FT                   /note="Exostosin GT47"
FT                   /evidence="ECO:0000259|Pfam:PF03016"
FT   DOMAIN          451..717
FT                   /note="Glycosyl transferase 64"
FT                   /evidence="ECO:0000259|Pfam:PF09258"
FT   REGION          34..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  84650 MW;  9A4448C5A117DBE2 CRC64;
     MQAKKRYFTL FSAGACLILL FCFGGIQVPL SRRGSNRPWE EDGSDDLDEH ISPRQKREAT
     SGVYTGKRCR MESCFDYSLC ERNGFKVYVY PQQKGEKMSE SYQNILSSIE GSRFYTPVPE
     QACLFVLSLD TLDRDQLSPQ YVHNLKAKIQ SLPLWNGGKN HIIFNLYSGT WPDYTEDLGF
     DIGLAMLAKA SISTENFRRN FDVSIPLFSK DHPRTGGERG YLKHNAIPPY RKYMLVFKGK
     RYLTGIGSDT RNALYHVHNS EDVVLLTTCK HGKDWQKHKD ARCDKDNFEY DKYDYREMLY
     NSTFCLVPRG RRLGSFRFLE ALQAACVPVM LSNGWELPFS EIIDWNTAAV IGDERLLLQI
     PSTVRSIHQD QILSLRQQTQ FLWEAYFNSV EKIVLTTLEI IQDRVLQHTS RSNLMWNSLP
     GGLFTLPQYS TYLGEFPFYY AKLGIKPYPK FTAIIHVVTP LVSQSQPVMK LLVAVAKSQY
     CAQVIVLWNC DKPLPAKHRW PLTSVPVIVI EGESKVISSR FLPYDTIPTD AVLSLDEDTV
     LSTTEVDFAF TVWQSFPDRI VGYPARSHFW DSNKARWGYT SKWTNDYSMV LTGAAIYHKY
     YHYLYTTYLP ASLKTMVDQM SNCEDILMNF LVSSVSKLPP LKVTQKKQYK ETMMAQVRQN
     LQVQVELCSN QSIGSRGSRW ADPDHFAQRQ TCMNKFASWF GTMPLVHSQM RLDPVLFKDQ
     VSILRKKYKD IERL
//