ID A0A3Q3WBF3_MOLML Unreviewed; 1109 AA.
AC A0A3Q3WBF3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000014211.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000014211.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q3WBF3; -.
DR Ensembl; ENSMMOT00000014440.1; ENSMMOP00000014211.1; ENSMMOG00000010844.1.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 2.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1048..1070
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 15..73
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 155..323
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 389..439
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 441..505
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 506..564
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 568..628
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1109 AA; 121571 MW; 2743FD0D9E87B0E3 CRC64;
SQEPIWHSQS FNVGTAGAKI FSGPAAEEFG YTVQQVANHE GKWLLVSAPW SGYNQNKKGD
VYKCQVTGSR NSCARLNLQD SVSIPDVKNL SDNMCLGLTL TRMPSASGSM MCGPLWGQKC
GNQDFHPGIC ARISPLFQPG PAFSPAVQTC GGAMDIVIVL DGSNSIYPWG PMNEFLQKLL
PELDIGPKNT QVSVIQYGVK PKFEFKLNQF TIKDEVISAA SKIEQMYWGF HQTNGGRPDA
AKVMVVVTDG ESHDSNIKEK VIAECEKQGI TRFGIAVLGY YNRNNIDTKN LIKEIKSIAS
LPTEKYFFNV SEEAALSTIT GTLGNRIFNI EGTGKGGDNF KMEMSQVGFS AHYSSKQDVM
MLGAVGAYAW SGTVVHQKGS NIDILPLSAF EGTLQDRNHS SLLGYSVTTL SDGSTEYFVA
GAPRSNHSGQ VIVYTVNAQK QSTIIDTERG KQIGSYFGSV LCSLDVDNDR VTDLLLVGAP
MFMSELKREE GRVYLFSVTK GILSEQGFLS GPSSTENARF GMAISAIPDV DLDGYNDVVV
GAPLEDKQKG VIYIYNGEKK MLKKEFSQRI LGSKLEPQLQ YFGRSLDSYQ DLNGDSLPDI
SIGAYGKVVQ LWSRGVASVT AEASFNPNKI NIFNKPCDIN GRKHSCFDTN LCFTASFRPK
NPVGPIDITY TLTLDADLQS SRVTSRGLFT KTNERFITGN TKISSSPLCL DYQVYVQEAP
DFVNSLFLKV EVEQQNADVN PVLDMFSPSA WEFSIPFTKD CGSDDVCVSD LVLSVTSDAK
ATSSAPVIVS ANNKQLSLQV AVKNLKENAY NTQVLVTYSS NLYYSNNFIV TCQVGYPVLK
RNQEVNMKFQ INFDYSFAQL QNRAEVKFEA KSDGKEEKPA DNKVDISIPV VYDAGIVLSR
QSNINFYVAD ATVPVKTMVK THDDIGPEFN FTVKVSTGNF PVSLLYLNVA LPMTTKGGNL
LLYVTSVDTQ VSACLMFLQS WKIASNSNDC KSAKCKYIKC ILKDIEVKSD YFVKIKTRIW
NGTFVTVNIF NNKIPWVSKP GEKGDVPLGV IVGSIIAGLL LLALAVGLLW KVKACLQLSV
LSQKCAALCV QITRKTLLFA PNSWATGYS
//
