ID A0A3Q3WCZ8_MOLML Unreviewed; 574 AA.
AC A0A3Q3WCZ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000006629.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000006629.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3WCZ8; -.
DR STRING; 94237.ENSMMOP00000006629; -.
DR Ensembl; ENSMMOT00000006753.1; ENSMMOP00000006629.1; ENSMMOG00000005182.1.
DR OMA; QENGDPQ; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06657; STKc_PAK4; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF17; SERINE_THREONINE-PROTEIN KINASE PAK 4; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 304..555
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 95..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 334
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 574 AA; 64512 MW; F1D35D8816B704DA CRC64;
MFTKKKKSRI QISAPSNFEH RVHTDFDEHE QKFVGLPRQW QSLIEDTAKR PKPFIDVTVI
TTVEPRKTIV RGSKMGVDGS LTWLLDEFDT MSVTRSNSLR RGSPPTQPRK DSSSSGVGQE
NGDPHHRHYS NPDRDQSDNR PKSSYMVRDG SPQSLRDKRP LSGPNIRTPN LPVTEGVIKT
AQHTSRPFNT YPRTDSEGGR SPTGQVRMAP IRHIESSPQN GPSGGSSRGS SNSKPSVSHP
HPHHTSQPSL TPEATQHPHT PHPNVPAPRP PGRSPQREPQ RVSHEQFRAA LQMVVDPGDP
RTYLDHYIKI GEGSTGIVCI ATVKTTGKLV AVKKMDLRKQ QRRELLFNEV VIMRDYHHEN
VVEMYNSYLV GDELWVVMEF LEGGALTDIV THTRMNEEQI ATVCLSVLKA LSVLHAQGVI
HRDIKSDSIL LTHDGRVKLS DFGFCAQVSK EVQRRKSLVG TPYWMAPELI SRLPYGPEVD
IWSLGIMVIE MVDGEPPYFN EPPLKAMKMI RDNLPPKLKN LHKVSPLLKG FLDKMLVRDP
AQRATASEIL KHPFLTKAGP PSCIVPLMRQ NRMR
//
