ID A0A3Q3WDT8_MOLML Unreviewed; 1430 AA.
AC A0A3Q3WDT8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000012808.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000012808.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 94237.ENSMMOP00000012808; -.
DR Ensembl; ENSMMOT00000013019.1; ENSMMOP00000012808.1; ENSMMOG00000009836.1.
DR OMA; WLLFRTH; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1430
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018729304"
FT TRANSMEM 744..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..182
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 184..275
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 282..377
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 380..481
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 487..588
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 897..1128
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1048..1119
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1160..1423
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1339..1414
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1430 AA; 161028 MW; 84E50DA76D8E5794 CRC64;
MTDHRGHLQA LLMVFPIITA GCTFEEDSDP NLCDFTQGEE DDFDWLLFRT YSSPSASSDL
LRGSYMLVNS SQHAVGHRAQ LLLQTLSEND THCVQFSYFL YSRDGHSPGA LRAYVRVNGG
PLGIPVWNTS GSHAKQWHQV ELAVSTFWPN EYQVLIEATV SREQRGYIAI DDIMVLNYPC
YKAPHFSRLG DEEVNAGQNA TFQCVAAGRA SEAEKFLLER HNGEILTAAS VKHLSHRRFV
VSFQLDNVQR TDQDLYRCVT QSSRGSGVSN FAELVVKVPP SPIAPPQLLR AGSTYLIIQL
NTNSILGDGP IIRKEIEYRA SQSPWSEVHG VNMVTYKLWH LDPDTEYHIS VLLTRPGEGG
TGPPGPPLVS RTKCAEPMRP LRGLIATDIQ SRQLSLQWEN LAFNLTRCHT YSVSLCYRYT
MAGGGGGHNT TVRECLAVEH NASRFTLRDL PPYHSIFVRL SLANPEGKKE GREVTFQTDE
DIPGGIAPES LTFTPLDDMI FLKWEEPVEP NGLITQYEIS YQSIESSDPG INVPGPRRTV
SKLKNETYHM FSNLHPGTTY LISVRARTAK GFGQTALTEI TTNISAPTFD YGDMPSPLGE
TDSTITVLLR PAQGRGAPVS TYQVVVEEDT VKKVKRELGL QECFPLPMSH GEAQARGTPH
YYTAELPPSS LPEASPFTVG DNLTYNGYWN SPLDPRKSYL VYFQAMSNFR GESRINCIRI
ARKAACKDHR KALEVSQHSE EMGLILGVCA GGLIVLILLL GAVIIIIKKG KPVNMNKTPI
TYRQEKSHMG SMERSFTDQS TLQEDERMAL SFMDAHTCGT RSDARSLVNE ASSLLGGSPR
HQCGRKASPY HTGQLHPAVR VADLLQHINQ MKTAEGYGFK QEYESFFDGW DCTKKRDKTK
GRHDTLLGYD RHRVKLHPLL GDPNSDYINA NYIDGYHRSN HFIATQGPKQ ETLYDFWRMV
WQENCFSIVM ITKLVEVGRV KCCKYWPDDS EMYGDIKITL LKTETLAEYT VRTFALERRG
YSTKHEVRQF HFTSWPEHGV PYHATGLLAF IRRVKASTPP DAGPVVVHCS VGAGRTGCYI
VLDVMLDMAE CEGVVDIYNC VKTLCSRRIN MIQTEEQYIF IHDAILEACL CGETAILMNE
FAVAYKEMLR VDSQSNSSQL REEFQTLNSV TPHLDVEECS IALLPRNREK NRSMDVLPPD
RALAFLVTTE GESNNYVNAA LADSFHRQAA FVVTPHPLPG TTADFWRLVF DYGCTAVVML
NQLNQSNSAW PCVQYWPEPG LQQYGPMEVE FLSMSADDDV ITRLFRVKNV TRLQEGQLVV
CQFQFLRWSA YRDVPDSKKA FLNLLAQVHK WQRECGEGRT VVHCLNGGGR SGTFCACNIL
LEMIQYHNMV DIFYAVKTLR NCKPNMVESL EQYRFCYDLV LEYLDCFDGR
//
