ID A0A3Q3WHU5_MOLML Unreviewed; 242 AA.
AC A0A3Q3WHU5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Zinc transporter ZIP9 {ECO:0000256|RuleBase:RU369011};
DE Short=ZIP-9 {ECO:0000256|RuleBase:RU369011};
DE AltName: Full=Solute carrier family 39 member 9 {ECO:0000256|RuleBase:RU369011};
DE AltName: Full=Zrt- and Irt-like protein 9 {ECO:0000256|RuleBase:RU369011};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000011792.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000011792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transports zinc ions across cell and organelle membranes into
CC the cytoplasm and regulates intracellular zinc homeostasis.
CC Participates in the zinc ions efflux out of the secretory compartments.
CC Also functions as membrane androgen receptor that mediates, through a G
CC protein, the non-classical androgen signaling pathway, characterized by
CC the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1
CC or ATF1. Moreover, has dual functions as membrane-bound androgen
CC receptor and as an androgen-dependent zinc transporter both of which
CC are mediated through an inhibitory G protein (Gi) that mediates both
CC MAP kinase and zinc signaling leading to the androgen-dependent
CC apoptotic process. {ECO:0000256|RuleBase:RU369011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369011};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369011}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556,
CC ECO:0000256|RuleBase:RU369011}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004198,
CC ECO:0000256|RuleBase:RU369011}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU369011}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369011}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|RuleBase:RU369011}.
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DR AlphaFoldDB; A0A3Q3WHU5; -.
DR STRING; 94237.ENSMMOP00000011792; -.
DR Ensembl; ENSMMOT00000011992.1; ENSMMOP00000011792.1; ENSMMOG00000009063.1.
DR OMA; HTELHAY; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR045891; ZIP9.
DR PANTHER; PTHR16133; SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED; 1.
DR PANTHER; PTHR16133:SF5; ZINC TRANSPORTER ZIP9; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|RuleBase:RU369011};
KW Ion transport {ECO:0000256|RuleBase:RU369011};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369011};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369011};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369011}; Transport {ECO:0000256|RuleBase:RU369011};
KW Zinc {ECO:0000256|RuleBase:RU369011};
KW Zinc transport {ECO:0000256|RuleBase:RU369011}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
SQ SEQUENCE 242 AA; 24796 MW; C79EEA6AAC34888C CRC64;
MDDFSSISLL SLAMLVGCYV AGTIPLAVNF SEERLKLVTV LGAGLLCGTA LAVIIPEGVH
ALYEEILEDP ESARVTSSKI TTTLGLVVHA AADGVALGAA ASTSQTSVQL IVFVAIMLHK
APAAFGLVSF LMHAGLERNR IRKHLLVFAL AAPVLAMLTY LGLSQSSKEA LSDINATGVA
MLFSAGTFLY VATVHVLPEV GGGGHSHSPA GGNGGKGLSK VEVGALVLGC LIPLVLSVGH
HH
//
