ID   A0A3Q3WIK7_MOLML        Unreviewed;       692 AA.
AC   A0A3Q3WIK7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMOP00000008644.1};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000008644.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000008644.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   AlphaFoldDB; A0A3Q3WIK7; -.
DR   STRING; 94237.ENSMMOP00000008644; -.
DR   Ensembl; ENSMMOT00000008798.1; ENSMMOP00000008644.1; ENSMMOG00000006681.1.
DR   OMA; SERCPQN; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd12926; iSH2_PIK3R2; 1.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00252; SH2; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50001; SH2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          3..80
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          296..391
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          585..680
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          85..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          403..437
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          475..523
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   692 AA;  78904 MW;  6AA92CBB0EF0A638 CRC64;
     MAVEGFQYLA LYAFTKDQEE DLDLQPGDLL TVSKASLLSM ENYKEGCAEH PEHLGWLLGY
     NERTKQRGDF PGTYVKYVGP VKMALPSSQP RSQRPLPAAP RLDSNQAVSM PDLSEQFTPP
     ETAPPTLVSL IQAIEKRGIS VSTGQHTCLL SVWPPSFRLH ATVSPSPSAS YGAVAGSHGR
     EVSLVLESST TVPLHHRLTL QYLLTHLAKV TQAQASNGLD THTLGQIFGP LLIQTGPSSP
     WSLDEEFAGL VVERLLIERT TEQDLTPPVL PAKPAKSKMA PSAMTDINSL LTDAEWYWGE
     ISREEVNEKL RDTPDGTFLV RDASSKLEGE YTLTLRKGGN NKLIKIYHRE GRYGFSEPLT
     FLSVVELINH YRHESLAQYN AKLDTKLLYP VSKYQQLVKE NSIEEVGEQL KVYHEQYQEK
     SREYDSLYEE YTRTSQELQM KRTAIEAFNE TIKIFEEQCE TQERYSRESL ERFQREGNEK
     EIQKIQSNSE RLKSRVKEIH DSKRKLEQDL RQQVSDNREI DKKMNSLKPD LMQLRKIRDQ
     YLIWLTQKGT RQKKINEWLG IKNDADDSYS LEEDEGSPHH DECTWYVGDI KRTQAEEMLR
     GKCDGTFLIR ESQSQKGSYA CSVVVDSDTK HCVIYKTATG YGFAEPYNLY SSLKDLVLHY
     KNVSLVQHND QLNVNLAYPV LASSQNQNQH PR
//