ID A0A3Q3WJF2_MOLML Unreviewed; 859 AA.
AC A0A3Q3WJF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=LRRC8 pannexin-like TM region domain-containing protein {ECO:0000259|Pfam:PF12534};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000008939.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000008939.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR AlphaFoldDB; A0A3Q3WJF2; -.
DR STRING; 94237.ENSMMOP00000008939; -.
DR Ensembl; ENSMMOT00000009098.1; ENSMMOP00000008939.1; ENSMMOG00000006904.1.
DR OMA; DFDHVCE; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..371
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 859 AA; 98656 MW; 3997BB4E67519509 CRC64;
MFTLTEVASL NDIQPTYRIL KPWWDVFMDY LGIVMLMLAI FSGTMQLTRD QVVCLPILEQ
TPERVGGFLG PKPPETADSL WDKESTIGEQ AAPLMAKRPP DSMAPTLRRF TQSGTFAQPQ
PTGVRTKLDF QQYVFVNQMC YHVALPWYSK YFPYLALIHT IVLMVSSNFW FKYPKTSSKI
EHFVSILGKC FESPWTTKAL SETACEDSEE NKQRLAGAST LLKHLSTSSE EGSPNQSAPM
LNKSGVTFSV ERLVSEVPSM TILDKKDGEQ AKALFEKVRK FRAHVEDSDL IYRLYAIQTV
IKTVKFILIL CYTMTFVASI DFNHVCEPEI KHLTGYTKFH CTHNMAFMLK KLLVSYIAII
CVYGIICIYT LFWLFRRPLK EYSFEKVREE SSFSDIPDVK NDFAFLLHMV DQYDQLYSKR
FGVFLSEVSE NKLREISLNH EWTFEKLRQH VTRNPQDKLE LHLFMISGVP DAVFDLTDLE
VLKLELIPEA RITAKISQMI NLQELHFYHC PAKVEQTAFI FLRDHLRCLH VKFTDVAEIP
SWVYMLKNLR ELYLVGNLNS ENNKMIGLES LRDLRHLKVL HLKSNLTKIP TNITDLSPHL
VKLVVHNDGT KLLVLNSLKK IMNLAELELL NCELERIPHA IFSLTNLQEL DLKSNNIRTI
EEIISFQHLK RLTCLKLWHN KIITIPMSIS HVKNLESLYL SHNKLESLPS SLFTLLKLRY
LDVSHNSIAV IPLEVGFLQN LQHFAINGNK VEVVPKQLFK CAKLRTLCLA HNCISAIPEK
IGQLSQLTHV ELKGNCLDRL PAQLGQCCLL RRSCLIVEDH LFDSLPTEVK DGINQESSAF
FPTFSTLVFI SSQENEALN
//
