ID A0A3Q3WJK6_MOLML Unreviewed; 159 AA.
AC A0A3Q3WJK6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC9 {ECO:0000256|ARBA:ARBA00016672};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000015038.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000015038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory protein for the calcitonin gene-related peptide
CC (CGRP) receptor. It modulates CGRP responsiveness in a variety of
CC tissues. {ECO:0000256|ARBA:ARBA00043924}.
CC -!- SUBUNIT: Component of the RNA polymerase III complex consisting of 17
CC subunits: a ten-subunit horseshoe-shaped catalytic core composed of
CC POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10,
CC POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and
CC POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and
CC CRCP/RPC9, protruding from the core and functioning primarily in
CC transcription initiation; and additional subunits homologous to general
CC transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-
CC POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription
CC initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both
CC transcription initiation and termination.
CC {ECO:0000256|ARBA:ARBA00044007}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC family. {ECO:0000256|ARBA:ARBA00006898}.
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DR AlphaFoldDB; A0A3Q3WJK6; -.
DR STRING; 94237.ENSMMOP00000015038; -.
DR Ensembl; ENSMMOT00000015284.1; ENSMMOP00000015038.1; ENSMMOG00000011491.1.
DR OMA; VMIINLR; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006384; P:transcription initiation at RNA polymerase III promoter; IEA:InterPro.
DR Gene3D; 1.20.1250.40; -; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR InterPro; IPR038846; RPC9.
DR PANTHER; PTHR15561; CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN; 1.
DR PANTHER; PTHR15561:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 13..139
FT /note="RNA polymerase Rpb4/RPC9 core"
FT /evidence="ECO:0000259|SMART:SM00657"
FT REGION 135..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 159 AA; 18016 MW; DFFD697E1B153510 CRC64;
MNGQLFSNVV YFLSRKNANA AMLSNYEVFK LLTDLKEQRK ESGKNKHSIG QQNLNTIMYE
TLKYLSKTPC SRQSPETVKE FLTTMMPHKL TKAEKLQVLN HRPQTAVEIQ LMVEESEERL
SEEQIEELIQ TVAGILPGDP EQENAAPTDA EMAEAGEQS
//
