ID A0A3Q3WMX3_MOLML Unreviewed; 392 AA.
AC A0A3Q3WMX3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Sex hormone-binding globulin {ECO:0000256|ARBA:ARBA00040510};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000016413.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000016413.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an androgen transport protein, but may also be
CC involved in receptor mediated processes. Each dimer binds one molecule
CC of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
CC 17-beta-estradiol. Regulates the plasma metabolic clearance rate of
CC steroid hormones by controlling their plasma concentration.
CC {ECO:0000256|ARBA:ARBA00037620}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR AlphaFoldDB; A0A3Q3WMX3; -.
DR STRING; 94237.ENSMMOP00000016413; -.
DR Ensembl; ENSMMOT00000016687.1; ENSMMOP00000016413.1; ENSMMOG00000012520.1.
DR OMA; NLSMPWE; -.
DR Proteomes; UP000261620; Unplaced.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24040:SF3; SEX HORMONE-BINDING GLOBULIN; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..392
FT /note="Sex hormone-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018723303"
FT DOMAIN 40..215
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
SQ SEQUENCE 392 AA; 42761 MW; 359E430EE37CB8AA CRC64;
MAVFRKAVAG RLLLTLSLAL LGRGAEGQGN GRGKVQVSGG ATVYLGQERD VWRPLIHTTI
NLSDISAIKS SFQLRTFDPE GTIFYGDTKN GVDWFVLSLK DGIPLMQIFK GGVHVSVAGG
AKLNDGKWHT LELSSQGKFV VLEVDGSNGL VVGMQSQEPE EVLSGELRLA LGGVLIDKDK
MIVQFEPQMD ACVRQGSWLN LSMPWETEAE ELWPCYENVR PGSYFPGTGM AIFNTSVFAF
EADQGVTAEL WGDFSMMDGT ILSIKTPGPM FTLVANNKTK DVTVAFGEKK IDIVVTVERL
QITFQTDLLR VRQDDDESKT TILSVIPVSH PGYLDTWRDG WLAVGGLLGE GEDEVGSQFL
KGCLEKIRVQ GRDLDLDLAV KHMSVTSHSC AA
//