ID A0A3Q3WPL0_MOLML Unreviewed; 411 AA.
AC A0A3Q3WPL0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Class E basic helix-loop-helix protein 40 {ECO:0000256|ARBA:ARBA00040229};
DE AltName: Full=Class B basic helix-loop-helix protein 2 {ECO:0000256|ARBA:ARBA00042387};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000014352.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000014352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q3WPL0; -.
DR STRING; 94237.ENSMMOP00000014352; -.
DR Ensembl; ENSMMOT00000014587.1; ENSMMOP00000014352.1; ENSMMOG00000010911.1.
DR OMA; MDSPALH; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19749; bHLH-O_DEC1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF3; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 49..104
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 139..172
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 184..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 411 AA; 45244 MW; 0D9FB44EA52E6476 CRC64;
MERITSAQPP PCVPKHAPLD ITEMQAMDFP IYVYKPRRGM KRGDESKETY KLPHRLIEKK
RRDRINECIA QLKDLLPEHL KLTTLGHLEK AVVLELTLKH VKALSTLLEQ QQQKIIALQN
DLQISDHVGN SAESSEEMFR SGFHLCAKEV LQYVASQESS RDLTPSHVVS HVQKVAAEVL
QHRSSLHPDE SVSHSSENVK RPAGQPQRAF EGPAKNCVPV IQRTNPSGTG EQSGSDTDTD
SGYGGEHDKR DPKAQWSERH AKEGELKRIV SERTTGAIKQ ESDEPKAKNS RSDSSDDEVL
HGHAAGGANS YMGFSPNQPP FCLPFYLIPP APAPVAAYLP MLEKCWYSGG MPVMYPGMSA
SAASLPPEAL TSSLVMSPRA GSPVPHHSPM DSPALHKALK PVPPLNLETR D
//
