ID   A0A3Q3WQK5_MOLML        Unreviewed;       186 AA.
AC   A0A3Q3WQK5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Ubiquitin-conjugating enzyme E2 C {ECO:0000256|ARBA:ARBA00039887};
DE            EC=2.3.2.23 {ECO:0000256|ARBA:ARBA00012486};
DE            EC=2.3.2.24 {ECO:0000256|ARBA:ARBA00039076};
DE   AltName: Full=(E3-independent) E2 ubiquitin-conjugating enzyme C {ECO:0000256|ARBA:ARBA00042725};
DE   AltName: Full=E2 ubiquitin-conjugating enzyme C {ECO:0000256|ARBA:ARBA00041791};
DE   AltName: Full=Ubiquitin carrier protein C {ECO:0000256|ARBA:ARBA00042389};
DE   AltName: Full=Ubiquitin-protein ligase C {ECO:0000256|ARBA:ARBA00042312};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000017433.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000017433.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-
CC         cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.24; Evidence={ECO:0000256|ARBA:ARBA00035845};
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC       {ECO:0000256|RuleBase:RU362109}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3WQK5; -.
DR   STRING; 94237.ENSMMOP00000017433; -.
DR   Ensembl; ENSMMOT00000017721.1; ENSMMOP00000017433.1; ENSMMOG00000013231.1.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR   CDD; cd00195; UBCc; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR023313; UBQ-conjugating_AS.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   PANTHER; PTHR24067; UBIQUITIN-CONJUGATING ENZYME E2; 1.
DR   PANTHER; PTHR24067:SF338; UBIQUITIN-CONJUGATING ENZYME E2C; 1.
DR   Pfam; PF00179; UQ_con; 1.
DR   SMART; SM00212; UBCc; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS00183; UBC_1; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362109};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362109};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|RuleBase:RU362109}.
FT   DOMAIN          32..180
FT                   /note="UBC core"
FT                   /evidence="ECO:0000259|PROSITE:PS50127"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
SQ   SEQUENCE   186 AA;  20433 MW;  CE573BCCD822A320 CRC64;
     MASQNMDPAA TTAASTAALK GNESGGSAAR GSVSKRLQQE LMTLMMSGDK GISAFPETDN
     LFKWIGTIDG AQGTVYDGLR YRLSLEFPAG YPYQAPRVKF VTPCFHPNVD DQGFICLDIL
     KDKWSALYDV RSILLSIQSL LGEPNNESPL NTAAAKLWGD QEEKELYESV YSLLNPLGPE
     WLYKEV
//