ID A0A3Q3WQP5_MOLML Unreviewed; 3974 AA.
AC A0A3Q3WQP5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000011379.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000011379.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 94237.ENSMMOP00000011379; -.
DR Ensembl; ENSMMOT00000011575.1; ENSMMOP00000011379.1; ENSMMOG00000008745.1.
DR OMA; FFQSCAK; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620}.
FT DOMAIN 1284..1423
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1925..2072
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 678..708
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2762..2827
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3974 AA; 451823 MW; 2890EE7B15A41BB2 CRC64;
MDRDSLQIYH LSTRKRQPFL PPLPSGVEPS KLYKTIWRNN LYPPLLQTGT RTLAAPYKEQ
RHCRTTSESI GNNYTPQAQD LKIKNLEDRG PPRPTLVKPG GPYKLLSFIH IKSCSHFMQL
VHVFTIKNPL VSSSPPPKKP LPRKVCTLSI PPMSPTQQLD IMHRQEEKMN AMEVEPTERD
LKASISEIID YILMDPDERK RVDINSIPKH FPSKVISAPV PWGAHYRDVH MRQSQHLFAA
TPIMVQLRDI WRNSFSSLRF VKLEDSISLP LRPSEFDEFV HRQCQSTRDV LLQKWLPQCA
SLLDTAQDLW LPLLSDNKQV AAVTSKEFFN CVAALMSLQL RKLVINSTTQ TLLRLIRLCF
FFVQLLQVKM QVKEPHIDFN PSFPQCWELI HSAFMEIISS AKELPRVQFS FIIKSLNQIL
PSLLNYTMQS AIFVLLWQVE CVLFTDLKSC YLHSVHPNES LVTDITSKAE EIFHKNTVGP
KKYLNVYEKH SNLMDGSATH DMSVFLEEKQ SFEGFSLLRK EIGSLYTMVP LSMFCLDASE
LNTDLRDRAQ TLSDTITTFV MKKNWEVNEG ICQRYEEITD TVECTPESTE ELVTLSQYIK
KTSDVTVQKL RDETNDASLR IFFLLDYAIL PCIKYSGSAN NLLTPALFVS LRLLQFNQML
QALDKEIHAF KKKQVMSLED MKKNLASLNQ ITLHLEEAIT ELEDINKEET LLDKVQSQFP
IIQTLIADKQ PYEQLWTTAL NFESMSEVWM NGPFKNLNAE KISDELDTMW RTANKLTKSF
SKFPGPLHVA KSCQNKIVQF KQHLPILSTI CNPGIKDRHW EKISSIVGFE IKPKEDSSLL
DMLNVGLSKF SDKLEDIGSV ASKEYSLEVA LEKMKNEWAD LQFSFSQYRD TDTNIVSAVD
DIQLLLDDHI IKTQTIRASP FIKPIETECK QWEETLLTVQ DILDAMLRCQ ATWLYLEPIF
SSEDIVAQMP EEGRKFAIVD GCWKKLMAGA VKDTRVLVAT CQPNMLQDLE ESNVFLDEIQ
KGLNTYLEKK RLYFPRFFFL SNDELLEILS QTKDPLCVQP HLKKCFEGIA KLEFTEDMAI
TGMISSENET VPFTEHIYPA DAKGMVEKWL LQVENLMLMS VRHVIHQGVI AYKEVPRKEW
VLQWPGQIII CASSIFWTEE VADAIENNTL PDYVKTCNSQ IGDIVELVRG KLPGGARMTL
GALTVIDVHA RDVVVKLAED NISSLDDFSW SSQLRYFWED DEVMLRMITT YLKYGYEYLG
NSPRLVITPL TDRCYRTLMG ALKLNLGGAP EGPAGTGKTE TTKDLAKALA KQCVVFNCSD
GLDYKAMSKF FKGLAQSGAW ACFDEFNRIE VEVLSVVAQQ ILCIQRAIAE NLKTFLFEGT
KLSLNPTCNV FITMNPGYAG RAELPDNLKA LFRTVAMMVP DYGLIGEISL YSMGFIESRS
LAQKIVATYR LCSEQLSSQH HYDYGMRAVK SVLTAAGNLK LKYPEENESV LLLRALMDVN
MAKFLAQDVP LFQGIISDLF PGVVLPKPDY DLLLKAINEN IARLNLQPVP PFIGKIIQIY
EMMLVRHGFM IVGDALGGKT CAYKVLAAAL GDIYKAKVME EFAVNYCIIN PKSITMGQLY
GCFDPVSHEW YDGVLATSFR NQASSTSPNR QWIIFDGPID AVWIENMNTV LDDNKKLCLM
SGEIIQMSSK MSLIFETDSL EQASPATVSR CGMIYMEPQQ LNWPPLRDSY MNTLPECLSS
EHREMVVDLF DWLVQPCLDF VETKCRFVIK TSPMHLVSSL MKLYTCLLDE IAASGNKNSK
MSCQQIGTWL QCLFLFAAIW TLGGTITGDC RVKFDSFYRD LIRGVDEEHP RPKSVKLNKN
NLFPERGTVY DYYFHKDGPG QWNVWTDLIS DEQKAIPAGA NVSDLIIPTM ETARQLYFLQ
TYLVHEVPML FVGPTGTGKS VINLSFLVNL PQEKYTPNCI NFSARTSANQ TQDIIMSKLD
RRRKGVFGPP TGKKCIVYVD DLNMPAKEIY GAQPPIELLR QWIDHSHWYD KKDTSRLNIV
DVLFLSAMAP PGGGKNDITG RVTRHLNIIS IDSFGDNTLN KIFTSITDWH FSNGFDGSFY
RQGKVMVQAT LAVYKECMNS FLPTPSKSHY IFNLRDFSRV IRGVLLAPHT HLEDGDKLIR
LWIHEVYRVF YDRLLDDKDK NTFFEIVKEK TSNIFKQSVE QVLSHLSPDG RVDDESIRNL
FFGDYTDPDA DVRAYDEIQE LGALQEVMES YLDEFNSSSK APMPLVMFKF AIEHVSRICR
VLKQDNGHLL LVGIGGSGRQ STTKLATFIN DYVLFQIELT KTYSTSDWRD DLKRLMLKAG
IEGKNVVFLY TDSQIKDEAM LEDISMLLNT GDVPNIFAAD ERADILEKMQ AIARMEGKKI
DSTPLSVYNY FIDRVKVLYS AAMSPIGDAF RNRLRMFPSL INCCTIDWFH VWPEDALEMV
AHKFLEDVEM DSTVRLEVVE MCKTFQTSVR DMSETYYSTL RRHNYVTPTS YLELILTFKT
LLNVKRNEVA TARDRYIVGL QKLEFATSQV SVMQEELKAL QPDLIKTSAE TDKMMTNIEG
ETMEVDAKRE LVSADEKVAN EAAAAAKAIK DECEGDLAEA MPALEAALSA LNTLKPSDIT
LVKSMTNPPG PVKLVMESIC IMKGIKPERK PDPKGSGKMV EDFWGPSKKL LGDLKFLDSL
KAYDKDQIPP TIIKKIREKF IDNPEFQPSV IKKVSSACEG LCKWVRAMEM YERVAKVVGP
KKERLKLAED ELSVQMEKLS VKRAELQKVE DRLQGLNDEL DIMIKKKKDL EDNIELCSQK
LDRAQKLIGG LGGEKDRWTE AARQLDIRYT NLTGDVLLSS GTVSYLGAFP VDYRAECQQQ
WHINCKEKKI PCSEVFTLSN ILGNQVAIRA WQIAGLPVDS FSTDNGIIVF NSRRWPLMID
PQGQANKWIK NMEKANKLAV IKLSDANYVR VLENSIQFGT PVLLENVGEE LDPVLDAVLL
KQTFKQQGVE YMKIGENIVE YCKDFLLYMT TGLRNPHYVP EVAVKVCLLN FMITPQGLQD
QLLGLVAAKE KPELEEKKNQ LILESAANNK QLKEIEDKIL KVLSTSEGNI LEDESAIQIL
SSSKVLSEEI SEKQKIASVT EKEIDVTCMG YRPVAEHSSI LFFCISELAN IEPMYQYSLT
WFINLYLCSI AESVKSDNVA ERINNIVDHF TLSIYKNVCR SLFEKDKLLF ALLLTVGIMQ
GKDEIDEQVW RFLLTGGIAL DNPYSNPAPE WLSDKSWSEI VRSSKLPNLG GFFKHVQDNI
SEWKKLYDSG KPHKDQLPES WDKLVGMDRM IVIRCFRPDK LVPAVQDFIV ANMGQAYVEP
PNFDLAGTYK DSNCCSPLIF VLSPGSDPTA GLLKFADDLK MGGDNTRTIS LGQGQGPIAA
QMIDNAIKEG TWVVLQNCHL ATSWMPTLEM ICEEIITPEN THDNFRLWLT SYPSDKFPVS
ILQNGLKMTN EPPKGIRANL LSSYLSHPIS DSAFFGSTSK PVVWQKFLFG LTFFHALVQE
RRTFGPLGWN IPYEFNESDL KISLRQIQMF LDDYEEVPLE ALTYLTGECN YGGRVTDDKD
RRLLLSLLST FYNQDLIDQE CYKLCEGDLY YIPAHGPHQV YVDYIRRLPI CTDPCVFGLH
SNADITKDNQ ETNQLLEGIL LTLPRQTGGG AKSPQEVVDD LAKDILSKLP SDFDIQKVMD
KYPVVYEESM NTVLRQEIIR FNRLTVVVRI SLVNICKALK GQIVMSTELD EVYNSMLVGK
VPSMWASKSY PSLKPLGSYV TDLLARLQFL QDWIDHDSPT VFWLSGFFFT QSFLTGVAQN
FSRKYTIPID FIGFEFEVTK EENNMEEKPE DGAYIKGLFM EGARWDRETM LIGESLPKIL
FDSLPIIKLR PGQMAYFKHE NIYVSPVYKT SARRGTLSTT GHSTNYVMPI ELPSDMPQKH
WINRGVACLL QLDD
//
