ID A0A3Q3WV61_MOLML Unreviewed; 2088 AA.
AC A0A3Q3WV61;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0000259|PROSITE:PS51456};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000013214.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000013214.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 94237.ENSMMOP00000013214; -.
DR Ensembl; ENSMMOT00000013427.1; ENSMMOP00000013214.1; ENSMMOG00000010130.1.
DR OMA; AMQLECC; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF8; UNCONVENTIONAL MYOSIN-XVIIIB; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000261620}.
FT DOMAIN 244..968
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1759..1818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2018..2074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1032..1293
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1347..1399
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1510..1586
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1649..1718
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 43..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1767..1795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2051..2070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 334..341
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2088 AA; 235214 MW; 4AE9FE8DB3ED2505 CRC64;
MALSSRLKLW EQKGGIREEK TPLVTADPPP PLSALPGGFL KQLVRDSEKE AKQKEAEVKD
ERPPSKVSDN LVQQFLLPDP TPPIPETEMA LRAEQLINDS SHIVAPDHQS KQETRQEVML
QPPRQQLDMK PEKSTKTPEA GQEREKVEEV KQVEQTEERQ EPDGRQADTS VTEHERREVR
DVWYEAGTVW YVHKDGFTLA TQLKPDEGTP ELPEGLVRVR LEMDGSLHDV TEYEIEKCNA
SEQDLCEDLS DLQSVNECGV LHTLMSRAKA NMPLSQAGPN LINFWPPLQT LSKITKPRRG
ESIWDAPPAL PALVKQVYES MVGTRRDHSV FAVGRSGTGK TTSCQAFTHA LLKQAGTTGE
KMMERVQAMF TILKSFGCVS SPHSDASSRF AMVFSLDFNH AGQAAAGHLQ TMMLDKWKVC
QTTPGESNFL VFSQMLAGLS TEMRTELQLH QLPETNAFGF VHPTKVEEKQ RASAAFTKLL
TAMETLDFSA GEQRAIWHVL AGIYHLGAAG ACRVGRRQFV SFDSAQMASN VLGCEGEELQ
TTVFKHHLRQ LLQRATGGSR ERNTATESEE GPRMTATQCV EGMAAGLYEE LFTAIVSLIN
RALSSQQLTL ASVMVVDTPG LRSPRHSAEE RGASWAELCH NYLQERLLEH YHTHTFTDTL
ERYIQEKIPV ELENPENSPA EVVLAIDQPP PQVRAADGDP RGLLWVLDEE MVMPGSSENS
ALQRVCQYYS NTVRQCEQPL QCEVNHLMGC DPVRYDLTGW FGLIQNNLSS LNAACLLQNS
TVGVVKAMFT PRISVPPLCR GLGGLEGGSQ RSLQRNGTIR KTFSGGMSAI RRHSQCIAVK
LQADALVNLI RRARPVFLQC VYAKTDSGSF DVPTLRVQLQ STQILSALQF HRTGYPEHMT
VSDFRCHFQA LSPPIMKRYA SMFVNHDERK AVEELLAELD LDKKSIVVGP SRVFMKRGVL
RYLEQQRDQQ VTGWLIYLQA SCMGHLARQK YRKLKVQQMA VSCLQRNLRA LRVVAKWSWW
RLFCRLRPLL DVNMENERLR AKEDEISALR RRLEKSERER NELRQTADSL DTKVTAVTSE
LSDERFRSDA VGQTLDVEKA ERLRLSRENK ELRVDQCKVT MGTLEKQLEE EKQRVEAASN
SKLAMQLECC QTEVEFVRRR LKQTEEKLEM EKQSRQQLET KVTTLQAHLE QSRRSTTELK
RQCRRVTSDL QDARVLTDSL QSRMHELERK QRRFDNELTQ ALEEAENERD QKDKAFQENA
MLGTDIYALR RSLQESQSEV DRLQKQKEEL CAQIRDLSLP VDLASDSLPD LKKQLRLLES
QASERSQEIT TLTAKIQQQQ QIHMRSEMEM ERMKQIHQKE LEDKEEELED VHKSSQRRLR
QLEMQLEQEY EEKQMVIHEK HDLEGLIATL CDQVGHRDFD VEKKLRRDLK RTHALLADAQ
LLLSTVDSQG QNLPNGSREQ IERLHCQLEE IDVRRLEAEC IQATLAQELE NTQIELENIC
KLKSMADEQL ALLQHEKMDL LKRLEEDQED LNELMKKHKA LIAQSSSDIS QIRELQAELE
EVKKQRHTLQ EELQQCMSRV QFLESTTVGR SIVSKQEARV CDLENKLEFQ RGQVKRFEVL
VLRLRDSVVR LGEELEQSAQ AEARERENAR YYQQRLQDMR MELEELTQRE QDSSRRRMDL
EMQVEELSAI RLTLQADLET SIRRIVDLQA ALEEVESSDE SDGESGLMAV ESLSRKKDLD
SVSSVGTEDV GEGIRKWLGV SKGGSRGGSP YGSSTISSQG GRRSITDTMS TYSFRSCADP
DDEAGDTRGL GRASSSSALS ELLDGLRKRR ASGSAGDESN SAVSLPIYQT TAASNLRRRA
SALSLGPDDL QEPRPGPSIL KSSSPLLPRA ASARSIGDAQ TSAATSAAGA KLSHFNPSDS
LSSFPSLPRL SALPLIQSGS SLIQRSPQGP RRCILGNLIT EDGGETSLGS ESMVFQNRLL
MGDNGRDDVA SDILPAVRRA QSTSSLASSV RGGRRALSVH FGELPASTRS KRSSETESSS
SGGSGGNSQD GRPRRRFERP QGERLEAEGS EGGDVASVMK KYLKKEMD
//
