ID A0A3Q3WW46_MOLML Unreviewed; 646 AA.
AC A0A3Q3WW46;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000022708.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000022708.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q3WW46; -.
DR Ensembl; ENSMMOT00000023084.1; ENSMMOP00000022708.1; ENSMMOG00000017253.1.
DR OMA; MENREYH; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 35..107
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 265..337
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 483..565
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 127..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..442
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 73029 MW; DC5938603A835B56 CRC64;
MLSASVKVIV KDPNGQGRMT NQLQFLQRTL LKCLWRHHFA WPFHEPVDAY RLNLPDYHKI
IKQPMDMGTI KKRLENNFYR SACECIQDFN TMFTNCYIYN KPADDIVLMA QSLEKIFLQK
VAQMPQEELE LPPPAPRNKN SKGRGRKSGE AQQVPAVSQS AYSPSSSDTG DSMLANSPQT
VLTKSVPPAN IMGLPPTQPR TKKKGVKRKA DTTTPSTMGV GSGRPIKPPK KDLPDSVQLQ
PSRKSKLSPQ LRYCSGLLKE MLSKKHVAYA WPFYTPVDAA ALGLHDYHDI IKCPMDLSTI
KRKVDCREYR DAQQFASDVR LMFSNCYKYN PPDHDVVSMA RKLQDVFEFR FAKMPDEPHM
DHTAMSLKSA PSSESEESES SPDSDSEEER AHRLAELQDQ LRAMHEQLAA LSQGPIIKPK
KKKEKKDKKE KKKKKKLEKR SRVGRSRAGS EEWKMPGKLL KTKSVRPGGS QAKKAQGKKS
NKNSKLEEEI VPMTYDEKRQ LSLDINKLPG EKLGRVVHII QSREPSLRDT NPEEIEIDFE
TLKPSTLKEL ERYVMTCLRK RPRKPYGEQA KSSIGKSKEE LTLEKRRELE RRLQDVSGQL
NSVKKPTKPK ETHTQPSRLS GSSSSSDSSS SSSSSSSSDT SDSDSG
//
