ID   A0A3Q3WZ51_MOLML        Unreviewed;       920 AA.
AC   A0A3Q3WZ51;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE            EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000020910.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000020910.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000435};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC         Evidence={ECO:0000256|ARBA:ARBA00000435};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000417};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC         Evidence={ECO:0000256|ARBA:ARBA00000417};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004888}.
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC       {ECO:0000256|ARBA:ARBA00005028}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
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DR   AlphaFoldDB; A0A3Q3WZ51; -.
DR   STRING; 94237.ENSMMOP00000020910; -.
DR   Ensembl; ENSMMOT00000021256.1; ENSMMOP00000020910.1; ENSMMOG00000015800.1.
DR   UniPathway; UPA00109; UER00180.
DR   UniPathway; UPA00242; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 3.40.367.20; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          22..221
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          229..462
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   DOMAIN          473..668
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          674..914
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   920 AA;  102189 MW;  4DD3B3D987462C7E CRC64;
     MFAVHLVSFF FSKLQEDPTK KVDRFLYAMR LHDDQLKEIS ARFQAEMKKG LSSDSNAAAA
     VKMLPTHVRS TPNGTEKGQF LALDLGGSRF KVLQVKVREG KGIRRGGVEM EEKTYQIPKD
     LLSGRGTELF DHVAESLKDF MHEKNISLEK KHLLAFTFSF ACEQSALDKG SLLHWSKNFR
     VRGLQGKDMV HVLREAIDRA GVGYEVLAMV NDTVATMMTC GFEDQYCEAG LIIGTGTNAC
     YMEEMCHVAL VEGDEGRMCV NTEWGAFGDD GALDDYITEF DRDIDAASNN PGKHIFEKMI
     SGMYLGEIVR LVVLKMAKLG QLFNGHVSNA LRTKGTLTTA HVAAMEEYKT GLKNTEHILR
     ELDLNPSPED CVAVQHVSTI VSFRSSNLVA AGLAAILTRI KKNRNLRELR ITVGLDGTVY
     KTHPQYPKRL HKVVRHLLPE CHVRFVLSDS GSSKGAALVT AVAQRLAARR RQVDETLSPF
     RLSQEQLTLV KNRMSAGLEA GLRCKGTSSV KMLPSFVYRT PDGKEQGKYL ALDLGGTNLR
     ALLVTFKTGL QQNTRMHHKI YTIPLEIMQG TGEELFDYIA YCISDFLDYM GMKKAHLPAG
     FTFSFPCEQT AIDTGKLVSW TKGFKATDCE GHDVVEMLRE AIKRRNEFDL DIIAMVNDTV
     GTMMSCAYED PQCEIGMIVG TGTNVCYMED LKNIEKTKQN ISKMCVNTEW GGLGDDGSLD
     DIMTPFDIEV NQNSINPGKQ RFEKLISGMY LGEIVRQVLL DLTRAGLLFR GRVTETLKTP
     GMFQTKYLSQ IESDRIALLQ VRSILQQLGL NSTCNDSIIV REVCAMVSRR AAQLCGAGMA
     AVVDKIRENR GLNHLNITVG VDGALYKLLL RFTIYFSSLN DLIQSNLALA PQCDVTFLPS
     DEGSGKGAAL ITAVARQKHI
//