ID A0A3Q3WZ51_MOLML Unreviewed; 920 AA.
AC A0A3Q3WZ51;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000020910.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000020910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR AlphaFoldDB; A0A3Q3WZ51; -.
DR STRING; 94237.ENSMMOP00000020910; -.
DR Ensembl; ENSMMOT00000021256.1; ENSMMOP00000020910.1; ENSMMOG00000015800.1.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR Pfam; PF00349; Hexokinase_1; 2.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 22..221
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 229..462
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 473..668
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 674..914
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 920 AA; 102189 MW; 4DD3B3D987462C7E CRC64;
MFAVHLVSFF FSKLQEDPTK KVDRFLYAMR LHDDQLKEIS ARFQAEMKKG LSSDSNAAAA
VKMLPTHVRS TPNGTEKGQF LALDLGGSRF KVLQVKVREG KGIRRGGVEM EEKTYQIPKD
LLSGRGTELF DHVAESLKDF MHEKNISLEK KHLLAFTFSF ACEQSALDKG SLLHWSKNFR
VRGLQGKDMV HVLREAIDRA GVGYEVLAMV NDTVATMMTC GFEDQYCEAG LIIGTGTNAC
YMEEMCHVAL VEGDEGRMCV NTEWGAFGDD GALDDYITEF DRDIDAASNN PGKHIFEKMI
SGMYLGEIVR LVVLKMAKLG QLFNGHVSNA LRTKGTLTTA HVAAMEEYKT GLKNTEHILR
ELDLNPSPED CVAVQHVSTI VSFRSSNLVA AGLAAILTRI KKNRNLRELR ITVGLDGTVY
KTHPQYPKRL HKVVRHLLPE CHVRFVLSDS GSSKGAALVT AVAQRLAARR RQVDETLSPF
RLSQEQLTLV KNRMSAGLEA GLRCKGTSSV KMLPSFVYRT PDGKEQGKYL ALDLGGTNLR
ALLVTFKTGL QQNTRMHHKI YTIPLEIMQG TGEELFDYIA YCISDFLDYM GMKKAHLPAG
FTFSFPCEQT AIDTGKLVSW TKGFKATDCE GHDVVEMLRE AIKRRNEFDL DIIAMVNDTV
GTMMSCAYED PQCEIGMIVG TGTNVCYMED LKNIEKTKQN ISKMCVNTEW GGLGDDGSLD
DIMTPFDIEV NQNSINPGKQ RFEKLISGMY LGEIVRQVLL DLTRAGLLFR GRVTETLKTP
GMFQTKYLSQ IESDRIALLQ VRSILQQLGL NSTCNDSIIV REVCAMVSRR AAQLCGAGMA
AVVDKIRENR GLNHLNITVG VDGALYKLLL RFTIYFSSLN DLIQSNLALA PQCDVTFLPS
DEGSGKGAAL ITAVARQKHI
//