ID   A0A3Q3WZH3_MOLML        Unreviewed;       239 AA.
AC   A0A3Q3WZH3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE   AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000018107.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000018107.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133}.
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DR   AlphaFoldDB; A0A3Q3WZH3; -.
DR   STRING; 94237.ENSMMOP00000018107; -.
DR   Ensembl; ENSMMOT00000018400.1; ENSMMOP00000018107.1; ENSMMOG00000013720.1.
DR   OMA; CDSMLRG; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR   PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620}.
FT   DOMAIN          30..231
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   239 AA;  25832 MW;  6D726FAF7BD2B9F4 CRC64;
     MQVLLLKEPR DGESGPDPYI KVATLLPLFQ PEKHGGLIFT SPRAVEAVKM CLEAEGRREE
     WYSSVKDRWN AKSIYVVGKA TAALVRNLGL VPFGEDTGTA EVLSCAIIER EDTNIPPLFF
     PCGSIKREVL PTALKDNGVP LETLTVYQTA EHPDLEKNLR NYFTEQGTPA SVAFFSPSGV
     KFCLDAVRRL SGGQLAQIKF AAIGPTTQDA MAAEGLCVSC AAEKPTAEHL AAAIAKALQ
//