ID   A0A3Q3X2S4_MOLML        Unreviewed;       525 AA.
AC   A0A3Q3X2S4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000016224.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000016224.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
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DR   AlphaFoldDB; A0A3Q3X2S4; -.
DR   Ensembl; ENSMMOT00000016494.1; ENSMMOP00000016224.1; ENSMMOG00000012381.1.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   HAMAP; MF_00313; Glutaminase; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   NCBIfam; TIGR03814; Gln_ase; 1.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          15..97
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
SQ   SEQUENCE   525 AA;  58819 MW;  D9B362EB952804B9 CRC64;
     VFVCFCRSRL MSSMEDLLFY TITEGQEMVT FSQFISALRK TGLLTTDPRL RDCVRQMQQA
     TRDSIGPVMM DKTLFRRCVG NNIMLLTKAF KKKFIIPNFA EFTQQIDRMY DSAQQQEAGQ
     VADFIPQLAK FNPDLWGVSL CTIDGQRHSV GDTKVPFCLQ SCVKPLKYAI AVHDLGSEHT
     HHFVGKEPSG FRFNKLSLNE DDKPHNPMVN AGAIVISSLT KVMDFLKRMA GAEYVGFSNA
     TFQSERETGD RNYAIGYYLK EKKCFPENAD MMAALDLYFQ LCSIEVTCES GSVMATTLAN
     GGICPITGER VLSTEAVRNT LSLMHSCGMY DFSGEFAFHV GLPAKSGVSG AVLLVVPNVM
     GMMCWSPPLD RLGNSVRGIH FCQELVSHFN FHNYDNVRHF VKKHDPRRKS DDQNKSLVNL
     MFAAYKTLFA LSAVNMEQTD YDSRTALHIA AAEGHVEAVI FLTEVCQVNP NMKDRWGNAP
     IDDAMEFGRD VIVSVLQNYQ RVYSKDSPSD AEKPNAMLEP AKSIV
//