ID A0A3Q3X3J9_MOLML Unreviewed; 388 AA.
AC A0A3Q3X3J9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Tumor necrosis factor receptor superfamily, member a {ECO:0008006|Google:ProtNLM};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000016539.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000016539.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A3Q3X3J9; -.
DR STRING; 94237.ENSMMOP00000016539; -.
DR Ensembl; ENSMMOT00000016813.1; ENSMMOP00000016539.1; ENSMMOG00000012603.1.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08315; Death_TRAILR_DR4_DR5; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034029; TNFRSF10A/B_death.
DR PANTHER; PTHR46874; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR PANTHER; PTHR46874:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..388
FT /note="Tumor necrosis factor receptor superfamily, member
FT a"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018761221"
FT REPEAT 78..118
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 78..118
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 119..156
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 119..156
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 312..377
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DISULFID 79..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 97..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 100..118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 135..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 138..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 388 AA; 43591 MW; A09D677C8BF52690 CRC64;
MTLVLAKIFL LWIWLFKPTG AFLRSDLDVR GGVGTRRAVH CRDELEYLNG RICCLNCPAG
TRLISPCSGA GEKGTCEECD YGTYTEHSNS LKQCFMCTRC RSDQDIVRAC SHTLNTECRC
KLGTFCPPDQ ACEVCRKCDK DEEVVRNCTP TANTVCKKIQ DKSVVPSVNN LVIVLPSLLA
AAVIVVADVC LNMSVPPLQP YSGDRPPDDG RNEESQRLSC SSLIKSRQTV RAKPSVHLED
ERKVLCESLN SSASNSQHSL SGLCAYSFPA TAPQASPTQP TRMNELLSLF AGEQSLRKCF
DFFEDIDINY HKRFFRLLEI GDNAIRSKEH LPYEDRIHEY LNIWIEKRGM DASLNDLLKA
LLDVNQRRTA ENIKEQALAR GYYLCQEK
//
