ID A0A3Q3X4X9_MOLML Unreviewed; 601 AA.
AC A0A3Q3X4X9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=NF-kappa-B essential modulator {ECO:0000256|ARBA:ARBA00040893};
DE AltName: Full=IkB kinase-associated protein 1 {ECO:0000256|ARBA:ARBA00041660};
DE AltName: Full=Inhibitor of nuclear factor kappa-B kinase subunit gamma {ECO:0000256|ARBA:ARBA00043239};
DE AltName: Full=NF-kappa-B essential modifier {ECO:0000256|ARBA:ARBA00041525};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000023185.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000023185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q3X4X9; -.
DR STRING; 94237.ENSMMOP00000023185; -.
DR Ensembl; ENSMMOT00000023570.1; ENSMMOP00000023185.1; ENSMMOG00000017641.1.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd09803; UBAN; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR InterPro; IPR032419; CC2-LZ_dom.
DR InterPro; IPR021063; NEMO_N.
DR InterPro; IPR034735; NEMO_ZF.
DR PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR PANTHER; PTHR31553:SF3; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR Pfam; PF16516; CC2-LZ; 1.
DR Pfam; PF11577; NEMO; 1.
DR Pfam; PF18414; zf_C2H2_10; 1.
DR PROSITE; PS51801; ZF_CCHC_NOA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01142}.
FT DOMAIN 571..601
FT /note="CCHC NOA-type"
FT /evidence="ECO:0000259|PROSITE:PS51801"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 206..261
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 358..385
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 436..515
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 100..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 68646 MW; 0A02A009581DD679 CRC64;
MVQPQPDGPM QWDISGEESG GALRVPPELA ANEVVTRLLG DNQQLREALR RSNLALRQRC
EEMEGWQRKT REDREFLSCR FQEARALVER LAQENHSLQG LVKGPGSSSS YCCSSSQTED
PQGRSVRNGL LDGLQTLEQR ERKRVEETDQ HTKTTPPHSG TSVCSSMSSI LPSFPISFSE
VAGKLIGREI GQLSLPMPVE GANEFLQLLK SHKEKLEEGM RELRKKNEEL ERERDEGEKE
RERMRRCIEQ LRTKLAQAQA SNATDEVVQH RSEAQHSSDW YRDLEEKLDH LQKSSAQRDR
TEALLKQKDK DYAQMAKDCE ALKAQATSLL GELNERQSCL EKSEHERIIL EEKLCSKIKT
LQVAERELEQ QKKQHNVAKD KLLLQTQSLE QALKTERHVV TEEKKKLTQL QHAYTCLFRD
YDSKLKAEGG DLCSRLEEAE RALALKQDLI DKLKEEVEQQ KGSLETVPVL TAQAEIYKAD
FLAEREAREK LNQKKEELQD QLNQAVAEID RLKQEATSRV RMEQMKLRHL EEFPARPPHI
PPPQAFNTVP PAPSFRNQGL IPVGDQGVTG AEELPDLCCP KCQYQAPDMD TLQIHVMDCI
Q
//
