ID A0A3Q3X8L9_MOLML Unreviewed; 945 AA.
AC A0A3Q3X8L9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000024600.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000024600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3Q3X8L9; -.
DR STRING; 94237.ENSMMOP00000024600; -.
DR Ensembl; ENSMMOT00000025011.1; ENSMMOP00000024600.1; ENSMMOG00000018698.1.
DR OMA; MTGQEMG; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF1; DESMOGLEIN-2; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 3.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 30..111
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 111..221
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 222..341
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 342..453
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 469..557
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 693..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 103484 MW; 875D2CD6BE23D181 CRC64;
KKREWITAPR QLKENHDYTG LQSIARIRSD KENHTQIMYF LSGPGVDETP KNVFGVDRVT
GFVKIYSILD REKIAFYYLQ GIAKYADGSY AEKIIGLNIT VVDENDCPPV IKAQQVGSVN
ESSATGTVVM KVIATDDDQV NTLHTKIFYS IVEQANTAGF FRINSQTGDV TVQRNTLDRE
KQDTYKLTIK AADLDGRAGG NTGTGEILIK ILDINDNIPT LEKESYEGSV EENTINVEVL
KIKAIDMDLI HTDNWLAVFK IISGNEAGYF SITTDSKTNE GIIMIRKALD YEELKVVHLE
VTVSNKAQYN FGSGSTAGGT ITQKSYTIKI NVVNQKEGPR FQPSVKVVII SEDQTSISLN
KIITRYAAID TDTLQTVTDV RYAKIRDDDN WLIIDEKTAD IKLNKLPDRE SKFLVNGTYY
AKIICITNDH PSKTATGTIA IQVEDYNDHC PTLTTRTQTM CYEDNFVYVT AIDQDEFPNA
APFDFTVIQE SNQGNWKVEP LNETTVILRG QDNLWPGNYK VTVEVKDQQG KSCTDVQVME
VIVCACHETT KTCVPRSAKT TTLGASGYKC EISVLVIPLL LLFCLCGGAA SAGDFKPIPY
DTKQQLISYH TEGQGEDKKS NHAAQQSQQK DSMLIYDYEG QESLAGSVGC CSLLENDNDL
SFLNDLGPKF KTLAEICQGS TIVTKSLSAG VSISPPRSLS PVRPSTSTHT HVHTHRETIR
DRDRVDINTL NTSKVAAGSF STVQEKQFTD RTQGLATTSK IHVQDNIMIP SQTMLVQQPT
MFYAATPMYV VEPNPQVVLV AGGTQQAVGQ VGVSQGLVQV SGLQGSQGVV LVDRQVGGLT
GKVSQGLIQG TGSGSRQVWV ENGSSGGGQA ISQGFVRIQQ GSAEQGLESR IHSKQVKTQS
ISHASTGLNK GFAQKATPKV HGSQKVVVQH KKVSLTERNV ESSSA
//
