ID A0A3Q3X992_MOLML Unreviewed; 940 AA.
AC A0A3Q3X992;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Extracellular calcium-sensing receptor {ECO:0000256|ARBA:ARBA00039746};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000022119.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000022119.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q3X992; -.
DR STRING; 94237.ENSMMOP00000022119; -.
DR Ensembl; ENSMMOT00000022484.1; ENSMMOP00000022119.1; ENSMMOG00000016799.1.
DR OMA; KCPDDSW; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF358; EXTRACELLULAR CALCIUM-SENSING RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..940
FT /note="Extracellular calcium-sensing receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018728359"
FT TRANSMEM 597..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..860
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 940 AA; 105492 MW; 595DCCB624B7A67C CRC64;
MRLALYYLML LGSSYVISTY GPNQRAQMTG DILLGGLFPI HFGVASKDQD LAARPQSTQC
VRFNFRGFRW LQAMIFAIDE INNSSSLLPN ITLGYRIFDT CNTVSKALEA TLSFVAQNKI
DSLNLDEFCN CTDHIPATIA VVGAAGSAVS TAVANLLGLF YIPQISYASS SRLLSNKNQY
KSFMRTIPTD EYQATGMADI IEYFQWNWVI AVASDDDYGR PGIEKFEKEM EERDICIHLN
ELISQYFEDH EIQALADRIE NSTAKVIVVF ANAPDVEPLI KEMVRRNITD RIWLASEAWA
SSSLIAKSEY LDVVAGTIGF ALKAGNIPGF REFLQKVQPK KDTHNEFVRE FWEETFNCYL
EDSPRQQESE NGSTGFRPLC TGEEDITSVE TPYLDHTHLR ISYNVYVAVY SIAQALQDIL
SCTPGHGLFA NNSCADIKKM EAWQVLKQLR HLKYTNSMGE KIYFDENADL EANYTIVNWH
RSAEDGSVVF QEIGYYNMHA RRGAKLVIDK TKIMWNGYSS EVPFSNCSED CEPGTRKGII
DSMPTCCFEC TECSDGEYSY HKDASICTKC PNNSWSNGNH TFCFLKEIEF LAWTEPFGIA
LAICAVLGVL LTAFVMGVFV RFRNTPIVKA TNRELSYVLL FSLICCFSSS LIFIGEPQDW
TCCIRQPAFG ISFVLCISCI LVKTNRVLLV FEAKIPTSLH RKWWGLNLQF LLVFLCTFVQ
VMICVVWLYN APPSSYRNHD IDEIIFITCH EGSVMALGFL IGYTCLLAAI CFFFAFKSRK
LPENFTEAKF ITFSMLIFFI VWISFIPAYF STYGKFVSAV EVIAILASSF GMLACIFFNK
VYIILFKPSR NTIEEVRCST AAHAFKVAAK ATLKHSTAVR KKSSSIGGSS ASTPSSSISL
KTNGNDCDAA SGKHRPRVSF GSGTVTLSLS FEESRRSSLM
//
