ID A0A3Q3XAH8_MOLML Unreviewed; 1124 AA.
AC A0A3Q3XAH8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Neuronal cell adhesion molecule {ECO:0008006|Google:ProtNLM};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000019294.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000019294.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; A0A3Q3XAH8; -.
DR STRING; 94237.ENSMMOP00000019294; -.
DR Ensembl; ENSMMOT00000019615.1; ENSMMOP00000019294.1; ENSMMOG00000014602.1.
DR OMA; RAHAPFF; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 986..1007
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..78
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 89..179
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 189..277
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 282..370
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 376..451
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 467..554
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 571..666
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 668..765
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 770..872
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 876..972
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1017..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 124585 MW; 1864656654D6BB82 CRC64;
YIIDPRENIV IHCEAKGKPH PSFSWTRNGT HFDIDSDPNV TMKPHAGTLV VDIGRVKAEH
YECVYQCTAR NKHGTAVSNN IVVRQSRSPL WSKEKIKPIV VQEGVSLVLP CRPPAGLPPP
IIFWMDNYFQ RLPQSSRVSQ SLNGDLYFSN VLREDSRNDY ICYARFPYTQ TIQQKQPITV
KVLSNERKPS FLIPSGPSSS TIVLRGQVLE MECIAEGLPT PEISWTKVSG DLPAKRTSFL
HYQRTLRIDN VSESDAGSYR CVARNQLGSV HHTIHVMVKA APYWISGAPR NLVLAPGENG
VLTCRASGTP KPSIAWFMNG IPIENSPKDP SRKVEDDTII FTDVQTGSSA VYQCNVSNDY
GYLLANAFVN VLSEPPRVLT PANKIYQVIK NHRALIDCAS FGSPIPKITW FKESRSSTLD
GDPYIIHDNG TLEIPSAQVH NGGKYTCAAR NILGIYENHV YLEVKEPTRI LKQPEYKVVQ
RGRSVVFECK VKHDPSLIPT MTWLKDDGEL PDDERFSIDS DRLTITDVAE NDAGVYTCIM
NTTLDHDSAS AELTVVEATP TPAVVYERPD PPTDLELTDQ KKRSVQLTWT PGDEHNSPIQ
KFQIQYEDSL HHPGHWHNLT EVPGTKTTAH LKLSPYVHYI FRVLALNAVG FSRPSFPSRM
FKTEAAAPDE NPTGVQGFGT RHDNLVISWK PLLGLQSNGP GLHYKVLWRQ KAVDSEWTSV
TVANNSKFIV SGTPTFVPFE LKVQAVNDHG AGPEPAIAQG YSGEDLPVAA PENVQALVVN
STVAEVHWDP VPTKLIRGHL KGFKVYYWKE RSLHKHNPHH VEKHILNFSG NHTRGMLPGL
HPFSLYSFSV RVYNGKGEGP PSHAQQFETP EGVPGAPSSL IVTSLSLDSL TLEWTPPHVR
NGHITGYTLK YQTVNNSNEV GPAEELALPA NETSVTLSNL KYSTRYKFYL NAQTVRGAGP
AISQEAVTVM DEAVASRQVD IATQGWFIGL MCAIALLILI LLIICFIQRN KGGKYPVKEK
EDAHTDPEFQ PMKDDDCTFG EYSDNEDHKP LKGSRTPSSG TVKREDSDDS LVDYGEGGDG
QFNEDGSFIG QYSGKSASRD TAEGPESSEA PSPINTMNSL NSFV
//
