ID A0A3Q3XCY2_MOLML Unreviewed; 468 AA.
AC A0A3Q3XCY2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Myocilin {ECO:0000256|ARBA:ARBA00017216};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000023644.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000023644.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}. Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion intermembrane space
CC {ECO:0000256|ARBA:ARBA00004569}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004294}. Rough endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004427}. Secreted, extracellular exosome
CC {ECO:0000256|ARBA:ARBA00004550}. Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00446}.
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DR AlphaFoldDB; A0A3Q3XCY2; -.
DR STRING; 94237.ENSMMOP00000023644; -.
DR Ensembl; ENSMMOT00000024038.1; ENSMMOP00000023644.1; ENSMMOG00000017995.1.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR23192:SF33; MYOCILIN; 1.
DR PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS51132; OLF; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..468
FT /note="Myocilin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018730956"
FT DOMAIN 202..462
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT REGION 135..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 52439 MW; 3AF5977FBBD511FC CRC64;
MWLQVLVLCL SCSPLFSQSQ AQDRATLHRS DDPAGRCQYT FTVASPNESS CSGGSLKPEM
DGVLSRLTLL EGLVSRLTAG ADGSAGADAE ATGEEVLQEA YAQVTLERNQ LEQENEQLNG
QVQELQRRLD EQVKEAESLR QKPCPQTHSA GGAQHENRPV RGMCIPQTLC SLEEHIYHPE
YDFGNGAYQE MKAEVTQVPA SRCGELLSVG DPVMHRKADS IAGKYGMWLQ DPEPQGSQYT
NKTVWRIDAV GKDIRQLFVY EDMDQFSHGF PMKVLVLPEP VESTGATIYR GSLYYQRKRS
RTLIRYDLAS ESLASRLELP HASFHGQHPY SWGGYTDIDL AADEQGLWVI YSTRKARGGI
VISQLDPGSL EVKKTWETKI RKNTVANAFM VCGRLYTVAS YTAPNTTINY VFDTQTGVGR
ALSVPFKNKY NYNSMVDYNH AQKKLYAWDS FHMVTYDITL GRAQQERD
//
