ID A0A3Q3XFD2_MOLML Unreviewed; 276 AA.
AC A0A3Q3XFD2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Dynein axonemal assembly factor 1 {ECO:0000256|ARBA:ARBA00024429, ECO:0000256|RuleBase:RU364076};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000021551.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000021551.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cilium-specific protein required for the stability of the
CC ciliary architecture. Plays a role in cytoplasmic preassembly of dynein
CC arms. Involved in regulation of microtubule-based cilia and actin-based
CC brush border microvilli. {ECO:0000256|RuleBase:RU364076}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU364076}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family.
CC {ECO:0000256|ARBA:ARBA00006453, ECO:0000256|RuleBase:RU364076}.
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DR AlphaFoldDB; A0A3Q3XFD2; -.
DR STRING; 94237.ENSMMOP00000021551; -.
DR Ensembl; ENSMMOT00000021908.1; ENSMMOP00000021551.1; ENSMMOG00000016376.1.
DR OMA; HNCIEDE; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF19; DYNEIN AXONEMAL ASSEMBLY FACTOR 1; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|RuleBase:RU364076};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU364076};
KW Leucine-rich repeat {ECO:0000256|RuleBase:RU364076};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|RuleBase:RU364076}.
FT REGION 245..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 276 AA; 31476 MW; 10DA1A1E4251FCDF CRC64;
MTKKFLKDHC KQNKLYLTPY LNDTLYLHYN GFSTIENLEE YTGLKCLWLE SNGIQRIENL
DAQTDLRCLF LQQNLIYKLE NLESLKKLCT LNVSNNYIHT VEHISCLPVL STLQIAHNKL
QTVGDIKLLS QCLAVSVLDM SHNLLSDPQI LSVLEAMPEL KVLNLMGNEV VKKIPNYRKT
TIVSLKQLTY LDDRPVFPKD RACAEAWAVG GLEGERKERE QWQEVETEDL TSMFSSQQVF
KPKIEVISGG TDEDEPTRNQ GEGVHSFGPE KDSVLS
//
