ID A0A3Q3XFI9_MOLML Unreviewed; 1088 AA.
AC A0A3Q3XFI9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMOP00000027550.1};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000027550.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000027550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q3XFI9; -.
DR Ensembl; ENSMMOT00000028020.1; ENSMMOP00000027550.1; ENSMMOG00000020652.1.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Signal {ECO:0000256|SAM:SignalP}; Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1088
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018594059"
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..287
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 403..704
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 718..832
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 847..1088
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 83..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1088 AA; 119595 MW; 062266E4AE590434 CRC64;
MERINFISQN LFLSCIGIYC CVCVSGDGNP KESSPFINSS AASDAEKSQQ YDGNNMALFE
EEMDTSPMVS SLLSSLANYS NLPTGSKEHE EAENNEEGSR PSKKPIKLGT LMGVYLPCIQ
NIFGVILFLR MTWMVGIGGV FGSFIIVFMC CSTTMLTAIS MSAIATNGVV PAGGSYYMIS
RSLGPEFGGA VGICFYLGTT FAGAMYILGC IEILLIYIVP QAAIFKIEGL EGPEAEAALL
NNMRVYGTIV LSFMSLVVFV GVKYVNKLAL VFLACVILSI LAVYAGVIKT AIDPPVFPVC
LLGNRTLISK GYDVCAKVIE IDNETVTTKL WRSFCDSEYL NATCDEYFSN NNVTEIQGIP
GITSGILAEN LFGNYLEKGA ILEKRGLPSD LDPDSSTTGT NRYVLADITS FFTLLVGIYF
PSVTGIMAGS NRSGDLRDAQ KSIPIGTIAA ITTTSTVLFD ANFSNNTVLD SCSPDMSTVV
LFGACIEGVI LRDKFGEGVN GNLVIGTLAW PSPWVIVFGS FFSTCGAGLQ SLTGAPRLLQ
AIARDGIIPF LRVFGHGKVN GEPTWALLLT ASICEIGIII ASLDSVAPIL SMFFLMCYMF
VNLACALQTL LGTPNWRPRF KFYHWALSFL GMSLCLSLMF ICSWYYAIIA MGIATCIYKY
IEFCGAEKEW GDGIRGISLS AARFALMRLE EGPPHTKNWR PQILVLVSMD AEQNVEQPRL
LSLTNQLKAG KGLTIVGTSV QGTFLNNFSE AQRSLRKLME TEKVKGFSQV VISSNLRDGT
SHLIQVGGLG GLKHNTVMVS WPRNWKQPEY HQQFRNFIEV VRETTVASMA LLVPKNISSY
PSNGERFTEG HIDVWWIVHD GGMLMLLPFL LRQHKVWRKC KMRIFTVAQM DDNSIQMKKD
LITFLYHLRI NAEVEVVEMH DSDISAYTYE KTLVMEQRSQ ILKQMHLTKN EMEREVQLIH
SKNVSSPTSP TSLMSPSVSA GGASAWTDSK AADKGSTLAT PNPEAGKDLF NMKPNQIDVR
RMHTAMRLNG VIMKKSKEAK LVLLNMPGPP KNRMGNENYM EFLEVLTEGL NRVLLVRGGG
REVITIYS
//
