ID A0A3Q3XPA5_MOLML Unreviewed; 628 AA.
AC A0A3Q3XPA5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000026636.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000026636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip.
CC {ECO:0000256|RuleBase:RU367070}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR AlphaFoldDB; A0A3Q3XPA5; -.
DR STRING; 94237.ENSMMOP00000026636; -.
DR Ensembl; ENSMMOT00000027091.1; ENSMMOP00000026636.1; ENSMMOG00000020172.1.
DR OMA; CCKHELY; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367070};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW ECO:0000256|RuleBase:RU367070};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW ECO:0000256|RuleBase:RU367070}.
FT REPEAT 31..64
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 628 AA; 72349 MW; 00F2C78541CCB814 CRC64;
YLSGVMTTIK DGEYTATIYK LVRMSAKAKS RAALSLLGYC YYHIQDFSSS AECYEQLTQL
HPEVEEYKVY YAQSLYKAGA FPEATKATFV LDNPSSHTKM LKLQACIKYC EEDYSVSLLE
QLPQEDSDYI YNMGCLLYQD GKYEEACKKF MSATQVLGYV PALSYNIALC YYSLKNYPQA
LKYIEEIIDR GIREHPELSV GMTTEGIDIH SVGNTLVLHQ TALIEAFNLK AAVEYQLKNL
KAAQEALTDM PPRSEEELDP VTLHNEALLN MDTKPSEGFE KLAFLLQQPS FPPVTFGNLL
LLYCKHEYFD LAADVLAENA HLTYKLLPPY MYEFLDALLT CQTAPEEAFR KFDEMSGKLT
EQLRKLAKQV FHLLPPLRFC TFVGPLYIVV LMAQTKIYWN RENFQMVEKI FRKSVEVCND
DDTWKLNVAH VLFMQNKYKE AIGFYEPIVK KHYDNILNVS AVVLANLCVS YIMTSQNEEA
EELMRKIEKE EEQISYDDPD KKVFHLCIVN LVIGTLYCAK GNYDFGISRV IKSLEPYNKK
LGTDTWFYAK RCFLSLLENM SKHMVMLRDS VVQECIQFLE HCEAYGKEVP ALIEQPLEES
RIHIGKNTVT YEARLLKALF YEVIGWNK
//