ID   A0A3Q3XPA5_MOLML        Unreviewed;       628 AA.
AC   A0A3Q3XPA5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000026636.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000026636.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip.
CC       {ECO:0000256|RuleBase:RU367070}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC       {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR   AlphaFoldDB; A0A3Q3XPA5; -.
DR   STRING; 94237.ENSMMOP00000026636; -.
DR   Ensembl; ENSMMOT00000027091.1; ENSMMOP00000026636.1; ENSMMOG00000020172.1.
DR   OMA; CCKHELY; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR   GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR   PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|RuleBase:RU367070};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW   ECO:0000256|RuleBase:RU367070};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW   ECO:0000256|RuleBase:RU367070}.
FT   REPEAT          31..64
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   628 AA;  72349 MW;  00F2C78541CCB814 CRC64;
     YLSGVMTTIK DGEYTATIYK LVRMSAKAKS RAALSLLGYC YYHIQDFSSS AECYEQLTQL
     HPEVEEYKVY YAQSLYKAGA FPEATKATFV LDNPSSHTKM LKLQACIKYC EEDYSVSLLE
     QLPQEDSDYI YNMGCLLYQD GKYEEACKKF MSATQVLGYV PALSYNIALC YYSLKNYPQA
     LKYIEEIIDR GIREHPELSV GMTTEGIDIH SVGNTLVLHQ TALIEAFNLK AAVEYQLKNL
     KAAQEALTDM PPRSEEELDP VTLHNEALLN MDTKPSEGFE KLAFLLQQPS FPPVTFGNLL
     LLYCKHEYFD LAADVLAENA HLTYKLLPPY MYEFLDALLT CQTAPEEAFR KFDEMSGKLT
     EQLRKLAKQV FHLLPPLRFC TFVGPLYIVV LMAQTKIYWN RENFQMVEKI FRKSVEVCND
     DDTWKLNVAH VLFMQNKYKE AIGFYEPIVK KHYDNILNVS AVVLANLCVS YIMTSQNEEA
     EELMRKIEKE EEQISYDDPD KKVFHLCIVN LVIGTLYCAK GNYDFGISRV IKSLEPYNKK
     LGTDTWFYAK RCFLSLLENM SKHMVMLRDS VVQECIQFLE HCEAYGKEVP ALIEQPLEES
     RIHIGKNTVT YEARLLKALF YEVIGWNK
//