ID A0A3Q4ADQ2_MOLML Unreviewed; 953 AA.
AC A0A3Q4ADQ2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000002110.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000002110.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q4ADQ2; -.
DR Ensembl; ENSMMOT00000002147.1; ENSMMOP00000002110.1; ENSMMOG00000001729.1.
DR OMA; SHTCRDL; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..953
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018571931"
FT TRANSMEM 876..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..388
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 474..517
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 518..560
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 561..604
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 605..649
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 747..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 21..33
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 28..46
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 40..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 60..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 67..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 122..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 144..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 151..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 163..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 185..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 192..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 232..244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 239..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 251..266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 271..283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 278..296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 290..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 319..337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 953 AA; 105379 MW; 330A036796BEA5B0 CRC64;
MWTDVGKLLM LHLLLAELHC CVSGQFQCKN GRCVPTLWRC DDDDDCSDNS DEENCPKKTC
ATTEFACKNG QCLPARWRCD GEPECPDGSD EADAICSRQT CPPEKFDCGG ATSKCVSLSW
RCDGEQDCEN GADEEQCAAD AKACPSNDFQ CHNGKCVAPI FVCDGDDDCR DGSDEEKCSA
PAPTCGQHEF RCNDSECIPA LWSCDGDPDC KDKSDESMER CSRRTEPQKP RCPVGEFQCG
SGECVHMNWK CDGDADCKDK SDEANCPLMT CRPDEFQCGD GSCIHGTRQC NKVRDCPDYS
DEAGCVNVTK CDGPGKFHCK NGECIDRSKV CDKVYDCKDG SDEPLNECDL NECADNNGGC
SHICRDQKIG YDCDCPPGYK LLDKKTCGDI DECENPDACS QICINYKGDY KCECYEGYEM
DPSTKTCKAV GKSPYLMFTN RHEIRRIDLL KSEYGQVVPT LKNAVALDVD VSTNKMFWSD
LYHRKIYSAY INKATESQVE LIDSLHSPEG LAVDWVHKNI YWTDSGNKSI SVATGDGRKR
KVLIATELSE PRAIAVDPHQ GFMYWSDWGD RAKIEKSGLN GVDRQVLVSE HIEWPNGITL
DLSNRRLYWV DSKLHLLSSV DLNGDNRKVL LSSHQQLGHP FALTVFEDHI YWTDLEDEAI
YSVNRLTGHD IAKVAEHLNN PLDLVVFHEQ RQPKAPDTCN MGSLPNGGCE YLCLKAPQIT
EHSPKYTCAC PDGMELGPDM RRCATVRPRT TTAPTTTTPA TVTTTSATPT STPATTTTTP
ATTTTLSTTT TSAATTLRPM TRRPTTPAPR QTPRSTSTKQ PRTPAAKSTE TSSLSSTHQT
STSTHTPLLA PMAPNSIQRE SNGNLSHRGK NLIHTVVFPI LATVVIGLLC TGGYLVWRNW
RSKNTKSMNF DNPVYRKTTE DDEDEIHIGR HSESIGHVYP AHVALSLEDD GYP
//
