ID A0A3Q4AQN1_MOLML Unreviewed; 4028 AA.
AC A0A3Q4AQN1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000006770.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000006770.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR STRING; 94237.ENSMMOP00000006770; -.
DR Ensembl; ENSMMOT00000006895.1; ENSMMOP00000006770.1; ENSMMOG00000005274.1.
DR OMA; PSPMCRE; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2812..3445
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3623..3953
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3996..4028
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 4028 AA; 459028 MW; 6052A710737175F7 CRC64;
MCSESSTAGG IHGLLLKLHE SLSDEDSRAA ALKCHDIIGD LGLECMLTST ENELALRTSL
LFSKDYGLLS FLRKSLVSEE LRDTRVEVLN FLEKFLDKVS PSVKGWERTY AIDIRVIVFV
KYSPQVLQKT KASSVAADLR ICEIFNRFYS ELCQKSKLPD SVLGKMYELL GILAEVHPSD
MVNNSDKLYK AYLGELKEQM TSSTKEPKLL VVAGCLRGIT ALMGNFPKTM EEDPETCKNI
FQYALKSIRP QVNVSAGLRL LARHASQFSS CLMDHYKALF DVMSKLCGHI NPEMKKTGYS
ALEAFLKQVA LLVAENIEEH KSKLKFFMQK FCGIIKTMDS THKELSIAIR GYGFFATPCK
KVCPQDVDLM YTELIQRCKQ MYLTESDGDD DSFYQLPSFL DSIASVLIHL DKIPEVYTPL
LERLLVVQID CFPEYSERMQ TVCCRSILKV FVAMASKGPV LWSFISSVVH QGLIRVCSKP
IMLNEVRFMF SDSSEVRIGL WKVPSSQNYL ALYKSLLDCD QLKDSGFLDG AFESQNSALV
SLSRLLYDEF IKSILRIVEK LDLSVQKVTT GDETLDDAAH ALPSSDPTAH LLPNKIKDFT
AFINLVDFCS ELLLSKHAEY FQCWVFPLSH ELVLHSIRNP LVSGFYKLLS VTMKISKKIK
YYQVIFQLVQ MKSGCFALFS KFGKEVCVRM KQYKDELLAS CLTFVLSLHH NIIALDIKAY
CPALEVALKL GLSHVPLANV ALDALEDWSS HIPLETMQPC YTTILPLLDG YLKAPSTNNK
DDRSWEVMSS VSLTREKGYS RVMTRLLKKS KQLTMEEAPL ITVRLRVVKL LGRLGGKLNR
NLVTVVSSEE MMKKFVAWDS EKRLSFAVPF ADMKPVIYLD PFLPHISDLA LSTSDRQTKV
AACELLHSLV VYMVGKSAQM VEGENSLPPM YKLHKRLFPV LLRLACDVDQ VTRQLFEPLV
MQLIHWFTNN KKFESQDTVA VLEAIVDGVV DPMDSTLRDF CGCCIGEFVK WSIKQTTPKQ
QDKSPTNMKS LFKRIYSLAL HPNGYKRLGA ALAFNSIYRL FREESSLVDQ FVFEVLVIFV
ESLALAHTDE PSMGTLQQCG SAIAHLKRII IHKAPSLNQH SAKRRIPRGI PLDGKLCLSD
MVLWLLEQCG RPQTECRHKC MGLFYEFIPL LPGKKSPPQW LDGMLKEHGI GFLISKFEGG
GLLSQPTLRD LTGPFSVRAT LQWMDLLLAA LDCYNTFINL HIIKPHHMLS SKEKSSFLKA
INFFLTELAS HELEVAESCF PRGEKSSHFS PREVDQYNFS KCTIIVRLLE FATMILVKGD
QEFWKLLEED IFASAFFELT ALVVCEPSTV GFNIADVEVM KNLPEVCVPA LKALMASPYC
SRIESSLRTK ISHKSVEELC AVDFYRSSTL SQHEQMEMVL SSCKQIHKAN FLSSILHSQD
ATYAKPLSSK LLMTVFKGIA PGEDRKALPS LDINTKRLAD GLLQLAFSLS QQSEQLVDLL
LNTMPLSGSQ SLNFLNFSHG EYFYSLFQTT INTELLRCQQ ITVPCLMKAA SENPAMVSLL
LNGMLDHSFS ERSVRKTQGK HLVEGVLRRW KSLQPWWEGH SATPESKTAT LLLLSKLLQI
DSSVCSDINH EAFRPVFSTF TVLLVDMSLP LNLKSQALLV LPFFTTLPEE PLVELQRALD
ALVVSHFPMQ SDEFAKGSLH RNNYMDCIRK LLHALELSQS PLLLKLMAGI LCRDKKHIME
EQFHTCFQRI AKSERQLQLM CTTYEVIQQD DVPMSFRLQA MMERVLLPLA SHCSTKALSD
FFVANVFDII ALLRDRFIKS NQTEFEIQLL KKTGCYKLME ILYSQLPKEE VYSKESRINQ
AYCRSEKTEG NELSKILIKS CFEAFTENMA GETQFPELRR LYHCAAYNCA ISAISYCFNE
AKFYHGFLFS EKPEKNQFIL ENIIDVTRTY NFPIEIEVPL ERKKKYVMIR KEVNEENGEA
PVYLSSQSYM ADSSLSEEMS QFDFSTGVQS FSFSSQNPEG HRRTETKPFQ DTLVDLEMDE
LNQHECMAVM TALIGHMQRN NITPKIEQGN TPSDLPPWMK FLHVKLANPA THLNIRLFIS
KLIINTEEVF RPYAKHFLGP LLQLVVSGNN GGEGIHFMVV DIVVTLLSWT SVASPKGNTR
DEVLANRLLE FLMKYCFHTK RAVFRHNLEI IRTLVECWKD CLHVPYSLIY ERFCGIDPNS
KDNSVGLQLL GIVLANNLPA YEASCGIEYG RYIESLTKNV SFVRYKDIYA AAAEIIGLIL
KNMTQMNDIT NLKKKDMDDK FIICLNKVSK HFPPFMDRFV NHVFFLLPKL HGILKTHCLE
CVLSRAEVIP DIFLQLQTTG FIQLMGHRDE ARQRVLLDII HKILPVLTPI QLQEFLGAVT
PFVSHPSPVC RERMYDILMW IQDNYSDEES MEDNTSLEVL NVAKETLLQG LSEENQGLQL
YVRNFWSQEK RLPTATLERM LTVLHSMYSS RIEKCFLSLA TNLLLEMTSQ SPDFKRNMFE
YPLSECTFQD YVIDSNWRFR STVMTPMFVE TQSSQGPESL AASQFGAMKG KLRATQTSLE
FSQTQTEGRR TAYNWLTGSS VDTLAEYTLG SDTASSLLVF DKKLERRTTA RRPVGEGFGM
KRLTASTDEV DSHTRAQNEQ RSNILRLRRR FLKDQEKNSL NYAHKEIQQQ RQKKKADQRL
RKEAQVTLYR NYRLGDFPDI QISYSNLITP LQALAQRDPI LAKQLFSSLF AGILQEMEKS
KPRAESGRIK EELRVNMNTF LSKSTLCFPP FIACVQDMCY QNKNLQQLDP AAISSTCLMS
LQQPSGILLL EEGLLHADGQ EEPPSKRPRG RKEIPLDTNK WIHLAKLYRS LEDYDVVRGI
FGGKVGTKSI TCSALQAEAK TDYAEAVKLY NEALNTNHWD DAEPTESEKD FWEIAAMEAY
SHLTEWKSLQ YCSTVYIDET SPPNLEKMWS EPLYQEMYLR HMIRSMLKQL QLGETDQTLL
SFIDKAMRVE ERKELLESHY SQELSLLCIL QEDYDRAKYY TNYAMELFME NYSSVDTLLT
QSRLTTLQSV QALTEIQDFL LFINGEVSVS SLKRLIKLWT ERYPDTKVDP VNLWDDIITS
RSCPQQQYGD GRFRRPSEES TVGIPSFVLS LFHHKLTLQQ LCCVQNNFAV ATKLLKDLHR
EAKTNRGWLL QWVHSYSHYS HRRSQTQGPV DQINAMLKTI PLLGKLEFFA PANVFRDQRL
LQGTSFNILA TAVNRRPSVL GMIEAEKAEG VAKLSGAEVE VGLQLQALKL FCGAIRKADE
ELQSYSQDCV ESSSIIETYM ALANFCDKQL REEDEKIEIK IKLTLLALPV HLVASMLKAL
KMNSEEARLK FPRLLQIIES YPSEAMDLMT KEMASVPCWM LIGWISQMVA LLDKPEAVAV
QHCITQIAVC YPQALVYALM ISSESYHFLS ACVCVNRLRS MLDKGGAVKT FVDALQQLTN
PEMIFKDWWD SVKNELDKPS FDKKRMSDMY DEMYSSLGDR NAASHGMFRR KFIQKFYKDL
EKLLGPKGSK LFDKRKEKGF VRQVEELAAS MRGFQKEPGN LKEYSPWLSG FKADTFSNEL
EIPGQYDGRS KPLPEYHAKI TGFDERVKVM SSIRRPKRLI IRGDDERDHP FLVKGGEDLR
QDQRIEQLFA VMNILLSHDA ACTQRGLQVR TYQVIPITTR IGLIEWMETT CTLKEFLYST
MTDEETKRVA RSPEVYNKWL STFAPNSNVS GIPLYGLAYK KAKRTETVSN YMKVLQLVPS
DLLRRAFLKM CNSPEAFLFL RSHFISSHAL LCVSHWVLGI GDRHLSNFMI NMDTGGMIGI
DFGHAFGSAT QFLSVPELMP FRLTQQFVNL MQPLKESGLI QSVMVHALRA YSAEPDLLLN
TMDVFVKEPS LDWKNFELKQ LKKGGTWTEE VNTKEINWYP LQKVNFARRK LEGANPAAIT
SEELKLGFEK DSAFSGMQSV ALGTKEQNIR ATLPATGLSV EKQVDCLLDQ AMDPNVLGRV
WVGWEPWI
//
