ID   A0A3Q4BDF5_MOLML        Unreviewed;       122 AA.
AC   A0A3Q4BDF5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Vesicle-associated membrane protein 8 {ECO:0000256|ARBA:ARBA00039271};
DE   AltName: Full=Endobrevin {ECO:0000256|ARBA:ARBA00042205};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000016855.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000016855.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004521};
CC       Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004521}.
CC       Early endosome membrane {ECO:0000256|ARBA:ARBA00037832}; Single-pass
CC       type IV membrane protein {ECO:0000256|ARBA:ARBA00037832}. Endosome
CC       membrane {ECO:0000256|ARBA:ARBA00037867}; Single-pass type IV membrane
CC       protein {ECO:0000256|ARBA:ARBA00037867}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00037845}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00037845}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00037863}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00037863}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00004211}. Zymogen granule membrane
CC       {ECO:0000256|ARBA:ARBA00037825}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00037825}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family.
CC       {ECO:0000256|ARBA:ARBA00008025}.
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DR   AlphaFoldDB; A0A3Q4BDF5; -.
DR   STRING; 94237.ENSMMOP00000016855; -.
DR   Ensembl; ENSMMOT00000017132.1; ENSMMOP00000016855.1; ENSMMOG00000012841.1.
DR   OMA; VRKKMWW; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042589; C:zymogen granule membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   CDD; cd15868; R-SNARE_VAMP8; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   InterPro; IPR001388; Synaptobrevin-like.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45701; SYNAPTOBREVIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR45701:SF7; VESICLE-ASSOCIATED MEMBRANE PROTEIN 8; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   SUPFAM; SSF58038; SNARE fusion complex; 1.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW   ProRule:PRU00290}; Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        83..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          19..79
FT                   /note="V-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50892"
SQ   SEQUENCE   122 AA;  13365 MW;  725AA6438777C5CF CRC64;
     FALGDPTREV GAQGEPQDKM QALRDQVDGV KGIMTSNVDR ILARGDRLDD LMDKSEDLQA
     GAQHFKQTSQ KVARSYWWKN VKLVMVIVII VVIIVLIIIL LATGVIPVSA PLPPVVKPTP
     NP
//