ID A0A3Q4BDM0_MOLML Unreviewed; 3212 AA.
AC A0A3Q4BDM0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMOP00000016960.1};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000016960.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000016960.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR STRING; 94237.ENSMMOP00000016960; -.
DR Ensembl; ENSMMOT00000017243.1; ENSMMOP00000016960.1; ENSMMOG00000012881.1.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..110
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 133..355
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 558..782
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1145..1244
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1938..2488
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2803..2980
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 2985..3068
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3074..3189
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 786..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2459..2478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..130
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 790..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3212 AA; 361901 MW; 86F70D48C4A54A3F CRC64;
MVFESLVVDV LNRFLGDYVV NLDSSQLQLG IWGGNRAWRL SISQLDIPFK VKAGHIGRLE
LKIPWKNLYT QSVEAILDGV YLLIVPTASI KYDPEKEERQ LQEARQRELQ RIEETKLKAA
EQENPDLEKQ DTFVEKLVTQ VIKNLQVKIS NIHVRYEDDV TNPNCPLSFG VALKNLSLQT
ADENWSPSLL DENSRLFFKV RKPTVSWQTD CIYVHFFFTV IDYSKHLTLQ TTQPSIIFRP
ISADAKLRMN PRSDVDFSSP KVDLTVNLSE VAFELNRAQY ISILELLGSV DMMSRNLPYR
KYRPMVQVHN NASLWWRYVI TGILEADVKP RLRMWSWQHI RRHRQMIKCY RELYKTKITS
KKPSEELLKS LEEVEKTLDI FNITLARQQA EVEASKAGLS IYRPGMKMEE EESQGWFSWV
WNWGGEADTN PKEVKTAGFD ELLTPDEKLK LYMAIGYSET AANPNLPKNF EDMKINFHME
RLSVSLKDNK DKREIIRLTV GELQSTLTQR PGAQAIKITA ELSLFEVTGL ASKRAAPTLL
SSRKAATGAG TPLLCILFET NPLDESANQR LHVESQPLEI IYDAITVNSM SAFFMLPDNL
QLDELTNATL MKLEQFRDRT ATGLMYVIET QKVLDLKVNL MASYVIVPQT GFYNGTQNIL
LLDLGHFKMS SLSRKHLPQL SVSSSNIEDI MSRAYDSFDV QLSSLQFIYS KPDGDWKMAR
KQKRSPLHIL EPVDLKVIFS RAMIVKDSRM AKYKMSGELP LLSLRISDDK LRSVLSLVES
IPLPESRPAA HGTASSSMTK SKLTPQLTPR RPLNIADQRS SLIFESCSEE DLFYDAPSSP
IDDRSFFADN PMPLRYADLN KRKSFLKEEG PKNMTDFIMT FEISEFSVQL CRLSGGQEVT
VLHLDIEGLG TELKLRTFDM TSNTYLREIY SEEKQVQLIT TLDNTEDDLL TLEYIKADKN
GPEFKSQHNN TEQLIKVTFS SLDVHLHTEA LLNTMNFLNN LLPPSIKKEG GQEELPTIPE
EDEAEKEGEK KAEAVVTRKK GSKKSKFADV INLHIRADLR CLKVYIRGQK ARISEISIEG
LVSEVLMRKR EMEVLANLKS IVILDCDKDA LYKKAVSIAD KEVFAFHMVN YTDATDGDSY
LDMSQVDTSV TLTVGCIQAI FLNKFVSSIL AFINNFQEAK EALAEVTVQA AEKAASGVKG
LAERSTRIAL NVHFNAPVIF LPQSSSSSNV IVADLGRLSV KNRFDKKPFK SDAKIPPVVD
IMTVKLADLK MYRTTYINES FQGETQLLKP VNLDLEIQRN ISSNWYHSIP DIEITAHLKP
LTLILSQDDM TVVLRTLSEN LSEKSDAVSP PALPPTTHPS SDFNKESQGH TVVTAAVVEP
QKNVKLKTTL KLNFTFDSMT LVLYSPHENV LLDSHDEQLK LAEFTLGTIS TSLHMFSDSS
MKASVQLATC LLDDKRPNIK MVTPRMIALR PGAEQNMMVE VNYRQGRDGT TLDTVVQDVY
LCASMEFLLT VADIFLKATQ QGFAQVPQSK NTAVSVVVSK TEMNVLVRNP EIVFVADLTR
ADAPALVMNT QCELLMKSSS EGSQMTAVIT DLKVVACPFL AEKRKNNVTT VLQPCEVFFQ
SSQSPTSPQA MEVSISALTL KVSPIIINTV ITIQSALTPT AETPEELESP VPVDLWEKRG
WKELKLWFLE EVGDEDTKSP APLIPQGESL QVNIRSICLT LEAGVGHCTI PMLLAKSSFH
GDVTNWSTLI NLHSELDMEV HYFNEILGVW EPLLEPLEDE TRDGFRPWRL ELKMKKKPVN
YTSLSDEMDC KIPDYKTVII ISSKDQLNIT LSKCGLAMLN NLGTAFAEAA KQTAESFQRD
EAPFLVKNRL GLPVSVRHSE MFCPVGQQST NLTVNLQDGE TLGMDYLTTT GSDQFSAMTS
LSGKDYYIQP TPMGHTSASV IPLIKVGRGM YSVMHKDSGV TRFLVCQISS VEGSKYIKIR
SPFQIINHFS IPFKVFEGST CLGSAVPNDE FCVPLDSYRS ELSLQPITEN DADDQGEQFE
SSEGFSYEDI SKLQPKARLR QTCRRCGGQG GVMMVNIVPV KDAVTFKHTG DAGENFDVPF
VLHLWPSILL RNLLPYPISY KLKDSGVLAP EATLNPGHSA QLHSAVINQS SLDLRLLNYF
AQDWSSEYSL QSDQEEITFI VFQSLQEDNE NDVIGTEMKR PELDIAVHVK YDLGQMVVAI
HSPYWMLNKT GRLLQYKADD IHRKHPLDYD MPLLFSFKPR YFLQNNKVRL MISESELSDD
FSLDTVGSHG DIKCKGRFKD YLVGVKIDAS SFSLTRIVSF VPFYTLVNRT KHSVFVCGQG
QDNWTEAQPE QSGIPFWPEN NTRRLQIKVG GCVLPPRTID FTRPENCLLL HMDNSVGGII
VDVNLSDHSA TIRFSEYHDG AAPFLIINHT KDQTLQFQQS AQEEITSWVA DELLDFSSSM
EEDSSQEEEE KEELEAGKAV HYTWAEPTGS RELCWKCGPY SGNLKSEKDL RENINNEGKL
FVISLYEGLQ RVVLFTEERR IYKLLCESEK AQLAEQEIIL SLQNVGVSLV NNSSSQEVSF
IGITSSDVVW ELKPKKKNRW KTLSTKETEL LESRFKEYTE SGPSDIATVQ LENGYQVCFT
PNAVDMRMLQ PYSAPLRRHF LPGLKIEYSV SSRQRAYRVQ IHRIQIQNQL PGSIFPFVFY
PVKLPKSITM DSEPKPLTDI SIVTRTAGHS DISRIKYFMV LIQEMDLKLD LGFVYALLDL
FTPENASITS SEQEVELFVK DMEHMKAELN NVYAADNSPI SLYEYFHISP IKLHLSFSLS
TGGEDGLKEQ REKELIPVQS LNLLLKSIGA TLTDVQDVVF KLAFFELNFQ FRTTQQLQWE
VIRHYSKQAI KQMYVLVLGL DVLGNPFGLI RGLSEGVEAL FYEPYQGAIQ GPEEFVEGMA
LGVKALVGGA VGGIAGAASR ITGAMAKGVA AITMDEEYQQ KRRETMNRQP SGFKEGLARG
GKGLVSGFVS GITGIVTKPI KGAQKEGAAG FFKGVGKGLV GAVARPTGGI IDMASSTFQG
IKRAAETSQD IKSLRPPRFI HEDGVIRPYK EREGLGSQML QKIENGRFAK YRYFAHAKVN
DSDFFMITKK GIFFVTKGTF GQLTCEWQYL FEEFTKDPMI VENRRLRIEA KERVKSVFHA
KEFGKIINFK TPEIATWVLS KLEDARESLP KY
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