ID A0A3Q4BHM0_MOLML Unreviewed; 650 AA.
AC A0A3Q4BHM0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000019060.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000019060.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR AlphaFoldDB; A0A3Q4BHM0; -.
DR STRING; 94237.ENSMMOP00000019060; -.
DR Ensembl; ENSMMOT00000019375.1; ENSMMOP00000019060.1; ENSMMOG00000014434.1.
DR OMA; HILVMRR; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.1280.180; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 45..634
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 365
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 650 AA; 73159 MW; 35983C35781B4E70 CRC64;
MDQVQRTLKQ SLPTASPDSK KVSSGEYLHQ SVVPTMHYQK SLPRLPVPKL EDTIRRYLAA
QRPLLDDDQF RKTEKNAEDF LNGVGRELHQ ELVAQDQNNK HTSYISGPWF DMYLSARDSV
VLNFNPFMTF SPDPKKEYND QLIRATNMVC SAGRFMKTLR AGLLEPEVFH LNPAKSDTDR
FKKFIRWVPS SLSWYGAYMV NAYPLDMSQY FRLFNSTRIP RRGRDELFTD EKERHVLVMR
KGNMYVFDVV DRDGNLVKPA EIQSHLKYIL SDPTPAPAFP LGVLTSENRD VWADLRDKVV
AAGNAEDLQI VDSALFCLCL DEDSMRDHIH MSHNMLHGDG CNRWFDKSFS IIITKDGQAA
INFEHSWGDG VAVLRFQNEV FKDTTEQPLV HPDSTAAAVD SASAVRRLQF KLDNELENGI
MKAKENFDLA VSKLTVDAME FRKGGKEGLK KCKLSPDAVA QLAFQMGFLR LYGQTVATYE
SCSTAAFKHG RTETIRPATI HTQRCSHALV QQPGQHSVEQ LKAMLNECSG YHGQLTKEAA
MGQGFDRHLF ALRYLASSKG QSLHNLYTDP AYAAINHNIL STSTLTSPAV SLGGFAPVVP
DGFGVGYGVH DNWIGCNVSS YPARNVREFL QCVHKSLEDI FTVLEGKPLS
//
