ID A0A3Q4BJW2_MOLML Unreviewed; 778 AA.
AC A0A3Q4BJW2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=KASH domain-containing protein {ECO:0000259|PROSITE:PS51049};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000020317.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000020317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR AlphaFoldDB; A0A3Q4BJW2; -.
DR STRING; 94237.ENSMMOP00000020317; -.
DR Ensembl; ENSMMOT00000020651.1; ENSMMOP00000020317.1; ENSMMOG00000015433.1.
DR OMA; QSRCSQQ; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 4.
DR InterPro; IPR026696; AKAP6/CEP68.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR14514:SF4; NESPRIN-2; 1.
DR PANTHER; PTHR14514; PKA ANCHORING PROTEIN; 1.
DR Pfam; PF10541; KASH; 1.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..727
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 749..778
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 719..778
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 381..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 89748 MW; 6D882EE4A0258968 CRC64;
MPLVYAHKCK NKLKETLVTV QQLDKNMSNL RSCLSRIEAE LSRPITYSVC HHHEIQRRLA
EQQELQKDIE QHTEGVASVL SLCDVLLRDE DAAGGTEVEG DSLQETSRSL DQRWRTICTM
ALDRRLMIEE TWRLWCKFLD DYSRFDDWLK MAERTAASPN SADVLYAVAK EELKKFEGLQ
RQVHERLTQL ELVNNQYRRL ARENRTDRAS QLKAMVHEGN RQWDSLHRRV AAVLRRLKYF
TSQREEFEGT RENMLVWLTE LDLQLTNVEH FSDSDVHHKI QQLNSFQKDI TLTTERIDGL
IVFGERLIQK SSPQDAVLIE DELEELHSYC QEVFGRLVRF HQRLSQPPMI REEPEPSTAT
FYLESSLELI GRPWLGRSQG SLPATPTHLL TSPLERSGRE TPVSVDSLPL EWDHTGDVGG
SSSHEDEEEE EEDEEEKAYF SALSGRLTAS NRFMLKKNKK KTPGFCVIER WELLQAQSGS
DQPACPQELH LLTSDLDDIT SWLESVIPVL ESLGQSDPAV SFEDMAARAK ELKEMQKKFA
QYKSIMLSVN LQAQEAPELQ DRLAAMNRDW SRACTGLQWW DISLRKTLVR CQRLHSLLLW
LAHAESRRYT VDISNPDTPV SALQNHQNTL RELKGRQTQQ ASLQALWSHL QPEEEVEDSD
EAQEKLHVTG SKLKLLLRQV EWDLSALQQR LVTNTSSKRK YADVNIWSML FNPVSNFYSS
LFYRVLRAAF PLHLLLLFLL LLPCLIPLSE SDPSCTGANN FARSFYPMLH YTNGPPPT
//
