ID   A0A3Q4BKP7_MOLML        Unreviewed;       530 AA.
AC   A0A3Q4BKP7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=uridine/cytidine kinase {ECO:0000256|ARBA:ARBA00012137};
DE            EC=2.7.1.48 {ECO:0000256|ARBA:ARBA00012137};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000020722.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000020722.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00000503};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00000734};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC       UMP from uridine: step 1/1. {ECO:0000256|ARBA:ARBA00004690}.
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
CC       {ECO:0000256|ARBA:ARBA00005408}.
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DR   AlphaFoldDB; A0A3Q4BKP7; -.
DR   STRING; 94237.ENSMMOP00000020722; -.
DR   Ensembl; ENSMMOT00000021068.1; ENSMMOP00000020722.1; ENSMMOG00000015767.1.
DR   OMA; FIRRRET; -.
DR   UniPathway; UPA00574; UER00637.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   CDD; cd02023; UMPK; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR006083; PRK/URK.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR000764; Uridine_kinase-like.
DR   PANTHER; PTHR10285; URIDINE KINASE; 1.
DR   PANTHER; PTHR10285:SF69; URIDINE-CYTIDINE KINASE; 1.
DR   Pfam; PF00485; PRK; 2.
DR   Pfam; PF14681; UPRTase; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          112..175
FT                   /note="Phosphoribulokinase/uridine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF00485"
FT   DOMAIN          180..267
FT                   /note="Phosphoribulokinase/uridine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF00485"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  59075 MW;  3A47F3C8FD1C4A25 CRC64;
     MTPPVFGSAP RRADMDTEVN DRNPNQQPTD EGMETDRSMS RSDSGSGEDS LDGLTNRVPR
     CPLTPSLSPP KRTTSQSKTE PPLLRTNKRT IYTAGRPPWY NVTGTTFKEA FVIGLCGGSA
     SGKTTVANKI IEALDVPWVV LLSMDSFYKV LNKEEQELAA KNEYNFDHPD AFDFERKEWK
     TVYGANVVIF EGILAFANKE LLKVFVDTDS DIRLIRRLKR DISQRGRDIS GIIKQYNKFV
     KPAFEQYIEP TVQAADIVVP RGGENFVALD LIVQHVHSQL EKVRIPQPVS VSALASAHQG
     QPLPKTLSVM ESTPQVRGMH TIIRNKETNR DEFIFYSKRL MRLLIEHALS FLPLKVTSVE
     TPQGGVYNGK RLSGKRITGV SILRAGETME QALMAVCKDI RLGKILIQTN HDTGEPELHY
     LRLPKDISED YVILMDSTVS TGAAALMAVR VLLDHDVAED KIFLLSLLMA EMGVHSVAYA
     FPKVCIITTA VDKEVNDQFH IIPGIGNFGD RYFGTDAPSD WCESDEGMDL
//