ID   A0A3Q4BSJ1_MOLML        Unreviewed;       948 AA.
AC   A0A3Q4BSJ1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMOP00000024297.1};
OS   Mola mola (Ocean sunfish) (Tetraodon mola).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Molidae; Mola.
OX   NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000024297.1, ECO:0000313|Proteomes:UP000261620};
RN   [1] {ECO:0000313|Ensembl:ENSMMOP00000024297.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q4BSJ1; -.
DR   STRING; 94237.ENSMMOP00000024297; -.
DR   Ensembl; ENSMMOT00000024706.1; ENSMMOP00000024297.1; ENSMMOG00000018481.1.
DR   OMA; CYKAYLT; -.
DR   Proteomes; UP000261620; Unplaced.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd08398; C2_PI3K_class_I_alpha; 1.
DR   CDD; cd00872; PI3Ka_I; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR002420; PI3K-type_C2_dom.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR000341; PI3K_Ras-bd_dom.
DR   InterPro; IPR015433; PI_Kinase.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   PANTHER; PTHR10048:SF95; PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00792; PI3K_C2; 1.
DR   Pfam; PF00794; PI3K_rbd; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   SMART; SM00142; PI3K_C2; 1.
DR   SMART; SM00144; PI3K_rbd; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS51547; C2_PI3K; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51546; PI3K_RBD; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          65..167
FT                   /note="PI3K-RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51546"
FT   DOMAIN          210..367
FT                   /note="C2 PI3K-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51547"
FT   DOMAIN          396..573
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          644..930
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   948 AA;  109522 MW;  CF83EC66795B21CE CRC64;
     MPVCEFEMMK DPEVQDFRRS ILSVCREAME EREGGGAHSQ ALYVYPPNLE SSPQLPQHIY
     GKLDKGRLIV TIWVIVSPSN SKQKYTLKVS HDSLPEQLIA ESIRKKSRSM HLSPQQLRLC
     VQEYQGQYIL KVCGCDEYLL EKYPLSQYKY IRSCIIVGRL PHLMLVSKDS LYSQLPASGF
     VTPSYSRRTP QPSPCPGGGD GSPPRSLWAF NTLLRVRLLC ATYVNVNIRD IDKIYVRTGI
     YHGGEPLCDN VNTQRVPCSN PRWNEWLTYD LYLADLPRSA RLCLSICSVK GRKGAKEEHC
     PLAWGNVNLF DYTDILVSGK VTLSLWPVPH GLEDLLNPIG VAGSNPNKET PCVELEFSWF
     NQTVVFPDEQ QIEEHANWTI SRELGYNYCH GLSSRLACDS SVSASDAEQL RSLCSRDPLY
     ELSEQEKDFL WRHRHYCVNI PESLPKLLLS VKWNSRDEVS QMYCLLKEWP LMEPESALEL
     LDCNFPDPMV REFALRCLVQ GLTDDKLSQY LLQLVQVLKY EMYLDNPLAR FLIKKALTNQ
     RIGHFFFWHL KSEMHNKTVS RRFGLLLEAF CRACGMYLKH LNRQVEAMDK LVNLTDTLKQ
     EKKDETQKTQ MKFLVEHMSR PDYMEALQGF VSPLNPVHQL GNLRLEECRI MSSAKRPLWL
     NWENPDIMSE LLFTNNEIIF KNGDDLRQDM LTLQIIKIME NIWQNQGLDL RMLPYGCLSI
     GDCVGLIEVV KNSFTIMQIQ CKGGLKGALQ FNSNTLHHWI KDKNKGEAYD RAIDLFTRSC
     AGYCVATFIL GIGDRHNSNI MVKENGQLFH IDFGHFLDHK KKKFGYKRER VPFVLTQDFL
     IVISKGIQES TKTKEFERFQ EMCYKAYLAI RQHASLFINL FSLLLGCGMP ELQSFDDIAY
     LRKTLALEKS QQEALEYFTK QMNDAHHGGW STKMDWIFHT IRHMPNEH
//