ID A0A3Q4EGL8_MOUSE Unreviewed; 712 AA.
AC A0A3Q4EGL8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Vomeronasal 2, receptor 120 {ECO:0000313|Ensembl:ENSMUSP00000157042.2};
GN Name=Vmn2r120 {ECO:0000313|Ensembl:ENSMUSP00000157042.2,
GN ECO:0000313|MGI:MGI:3644483};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000157042.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000157042.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000157042.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000157042.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000157042.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q4EGL8; -.
DR SMR; A0A3Q4EGL8; -.
DR Ensembl; ENSMUST00000234883.2; ENSMUSP00000157042.2; ENSMUSG00000090655.4.
DR AGR; MGI:3644483; -.
DR MGI; MGI:3644483; Vmn2r120.
DR VEuPathDB; HostDB:ENSMUSG00000090655; -.
DR GeneTree; ENSGT00950000183069; -.
DR Proteomes; UP000000589; Chromosome 17.
DR ExpressionAtlas; A0A3Q4EGL8; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038022; F:G protein-coupled olfactory receptor activity; IGI:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IGI:MGI.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 4.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF547; VOMERONASAL 2, RECEPTOR 118-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..712
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018531325"
FT TRANSMEM 449..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 447..709
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 712 AA; 79784 MW; 44C3D31DA48545EC CRC64;
MLIFVSVLLF LNFPVASCEP INPGCSLGMA DAIFQDGDVL VDCHFVLLTV SIALQKIFHF
LRFHLSFPMF IYRIHPNKYQ YVIALNFAIE EINKNIHLLP NISLGYDMYS IVQYQATILE
HSIRFLTGLK EAIPNYTCRK ESKLIAVVTG TSWEFPSRIS TILGLYKYPQ NPLGLFEIYG
IVFFTSLHIF FSHQLTFGPF DPMLSDHVKF PFIYQMAPED TSLALGMVSL MVHFSWTWVG
LIITENEKGI KFLSDLKREM KKNSVCAAFV QMLSLKYRYN WNDLLSTDPA IMGEMLHPFL
KNIQFNNPSG DKVDLSHTGK LETKYDIFNF WNFPQGLGLK VKVGTFSSFL PRNKQFSLSD
GMIEWGTKDK QTPLSVCSTS CAPGLMKSPQ EGKASCCFDC HPCLENEISN ETDSIQCIKC
PDDQYANTEQ THCIPKAVTF LAYEDPLGMA LACMALCFSA LTALVLGVFV KHHETPIVKA
NNRTLSYILL ISLILCFLCS LPFIGLPNMA TCILQQMSFG VVFTIAVSTV LAKTVTVVLA
FRSTVPGRRM RWILVSPNLI IPICTLIQMV LCAIWLGASA PFVDINAHNE RGHITIMCNK
GSATAFYCVL GYLGFLAMGT LTVAFWARNL PDIFNEAKFL TFSMLVFCSV WVTFLPVYHS
TKGKVMVAVE VFSILASSAG LLGCIFVPKC YIILIRPKNG SFKGLRGTRV CK
//
