ID A0A3Q4G066_NEOBR Unreviewed; 593 AA.
AC A0A3Q4G066;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Merlin-like {ECO:0000313|Ensembl:ENSNBRP00000001476.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001476.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_006784903.1; XM_006784840.1.
DR AlphaFoldDB; A0A3Q4G066; -.
DR STRING; 32507.ENSNBRP00000001476; -.
DR Ensembl; ENSNBRT00000001538.1; ENSNBRP00000001476.1; ENSNBRG00000001190.1.
DR GeneID; 102792829; -.
DR CTD; 405887; -.
DR GeneTree; ENSGT01020000230354; -.
DR OMA; QDEMRMA; -.
DR OrthoDB; 5476297at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000001190; Expressed in muscle tissue and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281:SF20; FERM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PIRSF; PIRSF002305; ERM; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 14..304
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT COILED 315..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 521..555
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 68..71
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
FT BINDING 287
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
SQ SEQUENCE 593 AA; 69422 MW; EA52947C6F69E94A CRC64;
MSILGLKKKQ PKTFKVKVIT MDAEMEFSCE VKWKGKDLFD LVCRTVGLRE TWFFGLRYTV
KDTYAWLKPD KRVLDQEVPK DSPITFNFLA KFFPEKVEEE LVQEITQHLF FLQVKKQILD
EEIFCSPEAS VLLASYAVQA KYGDYDPNFH KPGFLAQDEL LPKTVVMQYQ MTADMWEEKI
TAWYAEHRGL ARDEAEMEYL KIAQDLEMYG VSYFEITQNK RDTNLLLGVD AQGLHIYSPN
SKLTPNKSFP WSGIRNISYS EKEFTIKPLD KKKDVFKFYS SQLRVNKLIL QLCIGNHDLF
MRRRKVDSIE VQQMKAQAKE EKARKKMERQ ILAREKQMRE EAERAKEEME RRLFQLQDEA
RLANEALLRS EETADLLAEK AQIAEEEAKL LAHKAAEAEQ ERQRLEVTAM KTKEEKRLME
QKMREAEQLA VKLVEQSERR LKEADHLKQD LTEAKDAERR AKQKLLEITK TTYPLIAAYS
APPAPPAPPE AADFACESPP ARLDFKDSDM KRLSMEIERE RLEYMEKSKH LQDQLKELKS
EIESLKLEEQ QQQQASLYNL HSEARGYIPE PVYIAHSNRN SAYMSQMAFF EEV
//
