ID A0A3Q4G0G3_NEOBR Unreviewed; 1528 AA.
AC A0A3Q4G0G3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=T-lymphoma invasion and metastasis-inducing protein 1-like {ECO:0000313|Ensembl:ENSNBRP00000001510.1};
GN Name=TIAM1 {ECO:0000313|Ensembl:ENSNBRP00000001510.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001510.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001510.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 32507.ENSNBRP00000001510; -.
DR Ensembl; ENSNBRT00000001572.1; ENSNBRP00000001510.1; ENSNBRG00000001181.1.
DR GeneTree; ENSGT00940000156294; -.
DR OMA; MQFYIPQ; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000001181; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF4; T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 418..526
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 735..802
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 788..870
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 970..1164
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..39
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1528 AA; 172203 MW; 093FFE58387C396B CRC64;
MGNAESQNGD HALYGRGYLS RKHMSRSLRI SNKQSRRSRH ASSGKIEHRN SETSTRSSST
PSIPQSLADN GLEPFNETNI LPDFGSPIWV DRVAMNLRPV SFYNDLANPS MHITLPGPMA
EEVQDEDMYA GDVKYLQKTP DCSKETVGFK KRSKSADMWR DDSLEFSLSD VSQDHLTSTE
EIIDLTNERD FAGCEGHLQS SPTDSTDRAN SLDELYSQMS PASRQLHGRY AKWHNTNRAI
REGEDDKMLS PSDEDGNTYG AYTLPCRRSH CLSEGLTSHQ VEMCASMQGR RAQTIQDVTG
GEGSEYEDSG IDGVTVEPEL QSRRYKTMSA SFSVFSVHGR NMFTGSDSGS SSGGGGASEC
VQGVYENFRQ ELQMSSCQTE SLEEAGSALS DEQSTMSSAY QSDLLLSVVQ GMVRKAGKLA
VKNFLVHKKN KKVESATRRK WKSYWVSLKG CTLFFYETDG RSGIDNNSNP KHAIWVENSI
VQAVPEHPKK DFVFCLSNSL GDAFLFQTCS QTELENWITA IHSACATTVA RQHHREDTVR
LLRAEIKKLE QKIDMDEKMK KMGDMQLSAV TDTKKRKTIL DQIFLWEQNL EQFHMDLFRF
RCYLASLQGG ELPNPKRLLA FASRPTKLAM GRLGIFSVSS FHALVAARTE TGVRRRTQAM
SRSCSKRKSR FSSLWGLDTT SKKKTKAHPT VSQVCEVFHL LPKFPRLITA DKLLLPISQA
SILPDCDIWV PDHLTPSWVC LPNDQPVLTI IQPGESALCV LESICKAHQL DPTKHYLRLK
FLIENQVQFY IPKPEEDICD LVCFSISVVE EDGVQQLYIT DVKAGGLAFA KGLNAGDEIL
QLNGKDSHSL NFSDMKAAFS QASLALTVNT LPAVDRRQLC YLPPRRSDAE EDLYTDIFSQ
SQGSFCEIRT RFFLGVVLTV CESLKSTEQV AAFCRSLHDM NSLECVSSSP SPESPFPPPA
TPRQLSDADK LRKVICELVE TERTYVKDLN CLIGRYLTPL QKETFLTQDE LDVLFGNLPE
MVEFQVEFLK TLEDGTRLVP DLEKLERVDQ FKKILFSLGG SFLYYADRFK IYSAFCASHT
KVPKVLVKAK TDPNFKAFLD ERNPKQQHSS TLESYLIKPI QRVLKYPLLL KELFSLTDPD
SEEHYHLDVA MKAMNKVASH INEMQKIHEE FGAVFDQLIT EQSSEKKEVA DLSMGDLLLH
NTVTWINPPS SLGKWKKEPQ MATFGFHQQH QTPIANTLLT CLSCGPFFVC SHRVSVSSEE
KDPFRFRHMI PTDALQVRSM TNADGEGSAV CEIVHTKSES EGRPERTFHL CCSSPESRKD
FVKTVHSILR EKHRRQLLKT ESLPLNQQYV PFGGKRLCAL KGARPTINRA ASAPTRTLGR
RKLVRNRFTI DTDIVFDGDP EQQDLQQSDL AGDTDRWVEE QFDLEEYEDQ EEVKETDILS
DDDDDFCQTP TPTSIETDLE APVMALTLEG VEREKIKSPT ASETSDMAKQ RTTIKDKTED
QNQTEKDEIW VRRELTAIAT SGKLKAEL
//
