ID A0A3Q4G0K6_NEOBR Unreviewed; 1096 AA.
AC A0A3Q4G0K6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 3-like {ECO:0000313|Ensembl:ENSNBRP00000001676.1};
GN Name=NFATC3 {ECO:0000313|Ensembl:ENSNBRP00000001676.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001676.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q4G0K6; -.
DR Ensembl; ENSNBRT00000001743.1; ENSNBRP00000001676.1; ENSNBRG00000001353.1.
DR GeneTree; ENSGT00940000156131; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000001353; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF6; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 425..606
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 19..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1096 AA; 118690 MW; 8E6D91A0E4383C52 CRC64;
MTTANCPGNE ELDFRLIFGE EGQQQPLGPA DLEPDDNTSF YILNVGQPQS VVTNHQSMSL
PRHGMPSHSP IINTSRLQTQ KPGSEPPSYD TQDSKYGTSP MLPSAPAPKA FECPSIQITS
ISPSCPQEMD ANQEDLRANG PDGDYHSDRP LSRDHLYLPL DHSYRDSSLS PSPCSSLSSR
SWFSDASSCE SFSHVYDDVD SELNEAAARF NLGSPLTSPG CPSPQTGGGG VMEEQPHWQH
HQPTFVHQSH SISLSPRQSP CHSPRTSVTD ENWLSPRPPS RPSSRPTSPC GKRRHSSADI
CYPGSLSPHH SPTPTPGPSP RGSVTEDTWV GSPSVGMSPF QCCPSEADIP SKTRKTSQDR
TTMQTGKGEL GLDDQGNMSP NLDSPSDEAL HSLKKDGPAE QFLSVPSHFS WNKPKPGHTP
IFRTSSLPPL DWPLPSQFGQ YELKIEVQPK AHHRAHYETE GSRGAIKATS GGHPVVKLIG
YNEKPINLQM FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIMVSSTKV LEIPLLPENN
MSASIDCAGI LKLRNSDIEL RKGETDIGRK NTRVRVVFRV HIPQPNGKVL SLQAASIPVE
CSQRSAQELP QVEKSSLTSC LVSGGEEMVI TGANFFPESK VIFLEKGPDG RPQWEVEAKI
IHEKTQGSCI VVEIPPYHSK SVSSAVQVQF YVCNGKRKRS QSQRFTYLSV MVKQEHRDEL
DLPAVPPISM PRAPAGSLVR TQLPSPELGH PSDNLLSSSP HGLATGSGPG LLPVQTPCPS
LGSPSFQHLP QLQGRILHHP PADCQMTYHP NSAPLSVPPH SSYQPMQHSH GHSLPFNGQP
SLSPQGYERM PFQQSPSATS HPMGMGMLYP SSPCSSPTAP SSTTTNPIEG SPQSQQPLFT
PSCSHLQTLG SYHCSPTQVP SPGGHPLTGQ HSTPLQRAMG YHPVSQRSAS CPTTSSAPPP
RMVPSPHSGP SSPQLHSLPY QSPTSSSPTS GGSPLGPLQQ QHSGQLSPQA TSPVMTSLSP
AGVGPLVHPL SPQGPFQSDG ERLSIKQEPE DREPTFRSIG LQDITLDDGE MYDLIFLKHF
QWTVSQQLAL QGGESQ
//
