ID A0A3Q4G4C6_NEOBR Unreviewed; 1946 AA.
AC A0A3Q4G4C6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Myosin-10-like {ECO:0000313|Ensembl:ENSNBRP00000003031.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000003031.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000003031.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 32507.ENSNBRP00000003031; -.
DR Ensembl; ENSNBRT00000003140.1; ENSNBRP00000003031.1; ENSNBRG00000002329.1.
DR GeneTree; ENSGT00940000155159; -.
DR OMA; ENREHRS; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000002329; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0070650; P:actin filament bundle distribution; IEA:Ensembl.
DR GO; GO:0021555; P:midbrain-hindbrain boundary morphogenesis; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF24; MYOSIN-10; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF50084; Myosin S1 fragment, N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 31..81
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 85..760
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 638..660
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 908..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1673..1705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1842..1946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1842..1884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 178..185
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1946 AA; 226310 MW; CBD4A4A5C5E519F0 CRC64;
MTQRSGQDDP ERYLFVDRAV VYNPAAQADW TAKRLVWIPS ERHGFEAASI QQERGDEVVV
ELAENGKKAV INKDDIQKMN PPKFTKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI SGELERQLLQ ANPILESFGN AKTVKNDNSS
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AIRQAKDERT FHVFYQLLAG AGEHLKSDLL
LEGFNNYRFL SNGNIPIPGQ QDKDNFHETM EAMHIMSFGH EEILAMLKVV SSVLQFGNIV
FKKERNSDQA SMPDNTVKML EFTAERNTFR WQTADFAVEA LAKATYERLF RWLVHRINKA
LDRTKRQGAS FIGILDIAGF EIFQLNSFEQ LCINYTNEKL QQLFNHTMFI LEQEEYQREG
IEWSFIDFGL DLQPCIDLIE RPANPPGVLA LLDEECWFPK ATDKTFVDKL IQEQGTHTKF
QKPRQLKDKA DFCIIHYAGR VDYKADEWLM KNMDPLNDNV ATLLHQSTDK FVAELWKDVD
RIVGLDQVAG MNETAFGATY KTKKGMFRTV GQLYKESLTK LMATLRNTNP NFVRCIIPNH
EKRAGKLEPH LVLDQLRCNG VLEGIRICRQ GFPNRIVFQE FRQRYEILTP NAIPKGFMDG
KQACERMIQA LELDPNLFRI GQSKIFFRTG VLAHLEEERD LKITDIIIYF QSVCRGYLAR
KAFAKKQQQL SALKVLQRNC AAYLKLRHWQ WWRLFTKVKP LLQVTRQEEE LQAKDEELVK
VKERQLKVEN ELVEMERKHQ QLLEEKNILA EQLHAETELF AEAEEMRVRL LSRKQELEEI
LHDLESRVEE EEERNQSLQN EKKKMQSHIQ DLEEQLDEEE AARQKLQLDK VTAESKIKKM
EEDILLLEDQ NSKFLKEKKL LEDRIAEMTS QLTEEEEKAK NLGKVKNKQE MMMVDLEERL
KKEEKTRQEL EKAKRKLDAE TTDLQDQIAE LQAQIEELKI QLAKKEEELQ AALARCDEES
VQKNNALKQI RELQAQIAEL QEDLESEKMC RSKAEKLKRD LSEELEALKT ELEDTLDTTA
AQQELRSKRE LEVAELKKAI DEETKNHEAQ IQDMRQRHAT TLEELSEQLE QAKRFKANLE
KNKQCLENDN KELVCEVKAL QQAKTESEHK RKKLEAQLQE SLARATEVER AKGELAERSH
KLQTELDNVS TLLEEAEKKG VKLAKEVENL NSKLQDSEEL RQEETRQKLN LSGQIRQLEA
DKNNLLEQQE EDEEARRSLE KQLQSVQAQL FETKKKLEED VGAMEGLEEV KRKLQKDMEL
TNQRLEEKTM SLDKMEKTKN RLQQELDDQM VELDLQRQIV SNLEKKQKKF DQMLAEEKTI
SARYAEERDR AEAEAREKET KALSMARALE EALEAKEELE RFNKQLRAEM EDLMSSKDDV
GKNVHELEKS KRTLEQQVEE MRTQLEELED ELQATEDAKL RLEVNMQAMK AQFDRDLQAR
DEQGEEKKRA LVKQVREMEA ELEDERKQRS VAVAARKKLE MDLNELEGQI EAANKGRDEA
IKQLRKLQAQ MKDYQRELEE ARASRDEIFA QSKENEKKLK SLEAEILQLQ EDHAASERAR
RHAEQERDEL ADEISSSASG KSSLLEEKRR LEARITQLEE ELEEEQGNME LLNDRFRKAN
LQVGTLNNQL CHKLYLDQLE RQNKELKSKL AELEGAVKSK FKASITALEA KILQLEEQLE
QEAKERAAAN KIVRRTEKKL KEVMMQVEDE RRHADQYKEQ MEKANSRMKQ LKRQLEEAEE
EATRANAARR KLQRELDDAT EASEGLTREV TSLKNRLRRG GPVSSFSSGR SGRRNLNLDG
ASVDMSDDDA DSRSGDFNET PNTNVE
//
