ID A0A3Q4G4C9_NEOBR Unreviewed; 585 AA.
AC A0A3Q4G4C9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=N-acetylserotonin O-methyltransferase-like protein-like {ECO:0000313|Ensembl:ENSNBRP00000000888.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000000888.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000000888.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR AlphaFoldDB; A0A3Q4G4C9; -.
DR Ensembl; ENSNBRT00000000938.1; ENSNBRP00000000888.1; ENSNBRG00000000673.1.
DR GeneTree; ENSGT00940000162413; -.
DR OMA; AMHSSAK; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000000673; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IEA:InterPro.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00555; Maf; 1.
DR Gene3D; 3.90.950.10; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00528; Maf; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR029001; ITPase-like_fam.
DR InterPro; IPR003697; Maf-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00172; maf; 1.
DR PANTHER; PTHR43213; BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43213:SF5; BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF02545; Maf; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR SUPFAM; SSF52972; ITPase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 261..332
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 350..554
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
SQ SEQUENCE 585 AA; 64819 MW; 682549FF36CFCF6C CRC64;
MVLNPVISKL AGKLVVLASA SPRRLEILRS AGLRFEVVPS WFKETLDKGL FKAPHEYAVE
TAKQKALEVA RRMPFKHLKT PDIVIGADTI VSVDGMILEK PVDKHDAYRM LSSLSGKEHS
VFTGVAIVLC HEKENEEVDY QLVDFYEETK VKFADLSEDM LWEYINSGEP MDKAGGYGIQ
ALGGMLVEYV HGDFLNVVGF PLNHFCKQLH TQITPTASPA HKVCFYNSIT KICRLLTLFI
ENLPIANFVS ALPSTFPKTL QALFTASKLC LFDLLHSRPG LDAAQVAQEI KASEKGTECL
LEACVSLGLL KSIEKVYENA DLATDFLRSD APFSLHGYLQ HCNETMWPLF SHLESAVQEG
TSQREKAFSK HMLQKTSSSS REGKLRFMKA MHSIAKITGK TIATAFDLST YKSACDLGGC
TGALAYEFAE AHPGLSVTVF DLPAVVELNE FFHPQHPDNR VSFVAGDFLK DELPKADLYI
LARILHDLPD EKVHILLSKI ADACTAGCGL LLSEIFLDED RRGPSRGLLQ ALSMSEGKQR
SATEYSLLLK SHGFITAHIR HTDNLLDAML FTLLQCFSDS AEILD
//
