ID A0A3Q4G4J8_NEOBR Unreviewed; 423 AA.
AC A0A3Q4G4J8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Potassium channel subfamily K member 4-like {ECO:0000313|Ensembl:ENSNBRP00000000978.1};
GN Name=KCNK4 {ECO:0000313|Ensembl:ENSNBRP00000000978.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000000978.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000000978.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR AlphaFoldDB; A0A3Q4G4J8; -.
DR Ensembl; ENSNBRT00000001029.1; ENSNBRP00000000978.1; ENSNBRG00000000759.1.
DR GeneTree; ENSGT00940000160310; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000000759; Expressed in testis.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR008074; 2pore_dom_K_chnl_TRAAK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF30; POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01691; TRAAKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..131
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 168..246
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 284..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..376
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..406
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 46944 MW; BC9442EBAC153F40 CRC64;
MRCTTLTTLL VGVMLYLVMG AFVFVTLEKP TETLAHEKLL ETKKEFLMKN YCVTESDFHE
LVQAGLNVSR VPANLTTRWD IASACFFCGT IITTIGFGNL SPRTTYGQLF CVCYALVGIP
MFGILLAGVG DHMGTVLRRA VAKIETLFLK RKVRPTTVRV TSAVLSILIG CLIFLAVPTV
VFQKVENWKF LESLYFVVIT LTTVGFGDYV PGTEDNSFFK LLVLLWIVFG LAYFASILTM
IGNWLRVLSK RTRAEVGDSR NGSVRLAHMD TSERKDELIP AENYESAPNN SHNQAPDPSP
SSCSSSVPTS LPEVLLPCPD ITTAPSPSCQ LLDFFGENLA YIDESSDTLS DRPQSTSQEK
RRRPRKPKKK SMRRQLSYRR SSLQVRRPSS DMQPPSHPPT PPPAYSLSDL SLPENQTDAA
PAL
//
