ID A0A3Q4G4S3_NEOBR Unreviewed; 1626 AA.
AC A0A3Q4G4S3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anaphylatoxin-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001058.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR STRING; 32507.ENSNBRP00000001058; -.
DR Ensembl; ENSNBRT00000001111.1; ENSNBRP00000001058.1; ENSNBRG00000000743.1.
DR GeneTree; ENSGT00940000154063; -.
DR OMA; FPGNISE; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000000743; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.20.50.70; -; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048848; C3_CUB2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21308; C3_CUB2; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1626
FT /note="Anaphylatoxin-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018678882"
FT DOMAIN 659..693
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1475..1624
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1626 AA; 182535 MW; AE8B674D26ADC5E1 CRC64;
MRSSRGTYRT RLWLLASLAF LSLIFLTDGS PMKVMSAPNL LGVGTAQNIF VECQDCTDES
NLMVEISVMS YPTKSKRLIS TSVNLTSANK FQAFGQIKIP TQGFSRDPQR KQYVYLQAQF
PDVKLEKIVL VSFHSGYIFI QTDKTLYTPN SKVHYRLFAL TPNMEPVERD NSTISDTSVA
IQFVNPEGII FPLDTVSVKS GIHSGHFQLN EIVSTGLWKV MASFQSKPQS SYSAEFEVKD
YVLPNFEVKL TRENPFFYVD SDELTINIKA TYLFGEEVDG SAFGVFGVLH QDQKTNFQAS
LQKVSIENGV GTVTLKKEHI KQTFENISSL VGSSIFAAVN VLTDSGSEMA EIEVLNPDGS
PAQGVAVMID PGDVQGFTAA NGMARLTINT VNNPQPMKII AKTNDVKISP ERQASATMTA
LPYASQSNSY IHIGVDTAEV KNGQNMKINI HLSGQKNVQN DITYLILSRG QLVKYGRFRT
SGQIMISLII TVTKDLLPSF RIIAYYHPND NEVVSDSVWV DVEDSCMGSL QLHSEGGSKF
YEPRKIFRLK ITGDPEATVG LVAVDKGVYI LNSKHRLTQK KIWDSVENYD TGCTPGGGKD
SMSVFYDAGL LFESNTASGT PYRQELKCLN PNRRKRAVDM MNVTTTLLSQ YKDKLEHDCC
LDGIRETPTS SNCEKRSEFI ADTACFEAFL HCCKEMEKKR AERKEDGLKL ARSEDDDSSF
MDSNEIVSRT NFPESWLWSD MKLPACPEGN PNCEKESVLR NIPLQDSTTT WQLTGISLSK
THGICVGDPL EIVVRKDFFV DLKLPDSAVR GEQLEIKAVI HNHTPNPYTV RVDLTEAEHV
CSAASKRVRY RQEMKVGAKS IRSVPFTIIP TKEGQHRIEI KAAVKESEIS DGIVKMLRVV
PEGILIKSSH TLTLDPKQRG TDGRQVEILN SKIPVIDFVP NSPTSTQISL TGKQQRNVLK
NTISGESMGG LIYQPSGCGE ENMIHMTLPV IAITYLDRAD LWEIVNIDLR DQALQHITTG
YHNQLEYSKK DGSFARTQDE PSSTWLTAYV VKVFALANNL IAVQSEVICN AVRFLIVNTQ
QRNGMFMEVG SVSLKEILGD VLDTDSDASF TAFCIISMQE SRTICAPTVH NLQASIDKAV
GYLERRLPSL VNPYAVAITS YAMANENKLN REIFFKFSSP DSSYWPSPAG RVFTVEATAY
ALLALVRAKA FDEARPIVRW FNKQIRENGG YGSAQATMTV YQAIAEYWTS EKEPEYDLNV
DILLPGRSKP DKYNFNWENH FATRTSKINV INQDVKVSAT GPGEATLTIT SLYYELPKEK
ENNCQKFNLS VQLLPESLGD DENIYNLKIK VFYKNKERNA TTPVLDIGML TGFTVSTKDL
DLQAKGHART ISKYRLNTES ERSLLTIYLN KVPYTELEIA FRVHQKLKVG ILQPASVYVY
EFKTKCVRFY HPERKAGELL RLCRNDECIC AEENCSMQKK GKINNDERKD KICETTVRSK
IDFAYKVSVE QFKDGLSTDI YTVQVLEVIK EGSYDVGPQG RQRMFLGYPH CRMALDLGVG
KTFLMMGTSG DIFKDEKSQS YQYVLGERTW IEYWPTVTEC TTEEHNITCL AINEMVNEYM
IRGCRN
//
