ID A0A3Q4G670_NEOBR Unreviewed; 857 AA.
AC A0A3Q4G670;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSNBRP00000001673.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001673.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001673.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q4G670; -.
DR STRING; 32507.ENSNBRP00000001673; -.
DR Ensembl; ENSNBRT00000001740.1; ENSNBRP00000001673.1; ENSNBRG00000001348.1.
DR GeneTree; ENSGT01050000244874; -.
DR OMA; QCTGHED; -.
DR Proteomes; UP000261580; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..857
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018725947"
FT TRANSMEM 587..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 588..852
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 857 AA; 95957 MW; E251166999F82456 CRC64;
ENPLGWALLQ LLLVASASYA EEPVCRQRGD PENPLLSKNG DIILGAIFSF HASWKDRKDS
YMNKPLPLQC ISLNFRDLQF AQAMLFAIEE INNNTDLLPG ISVGYKIYDD CGSNARSAGV
TLALANGNEI VSVPSKTPCT RPAHVQAIIG ATSSSTTIAV STVIGPFFIP VISYFATCAC
LSDKTKYPSF LRTIPSDYYQ SRALAHLVKY FGWTWVGAIR TNSDYGNNGM ATFTETAQQL
GICLEYSVSF FRTDPYSKIQ RIIDIIKAST SKVIVTFLAR ADFHVLLREF SYYNLSGYQW
VGSETWIFDS RTAEMDTHHI LDGAIGLSIP KAHVTGLREF VLNEKPLNSS NNELFIEFWE
TLFNCRFRQS ASSADIQKEC TGHEDVTGVQ NSFIDMSLMP LFNNVYKGVY AVAHALHNIL
SCNKTCNRNV QLDPFMVLQH IRKIHFTTKE GDEVHFNENG DPAAKYDIIN WQPRENGVVE
FVTVGLYNPS LVPEKQLNLQ NKSLIWARNS KQVPLSVCSE KCPPGTRKVL QKGRPVCCYD
CIRCAEGEIS NVTDSVTCVR CLPEFWSNER RDACIKKEEV FLSYEDIMGA LLTAASLFGA
CMTIGVILIF FKYRKTPIVR ANNSELSFLL LFSLTLCFLC SLTFIGQPSD WSCMLRHVAF
GITFVLCISC LLGKTMVVLM AFRATRPGSN VKKWFGQTQQ RLCVTAFTLI QVNICIIWLT
SSPPFPFKNF KEIKDKITLE CALGSAIGFW AVLGYIGLLA ILCFIFAFLA RKLPDNFNEA
KFITFSMLIF CAVWITFVPA YVSSPGKFSV AVEIFAILAS SFGLLICIFI PKCYIILLKP
EKNTKKYMMG KKAPNSL
//
