ID A0A3Q4G6W9_NEOBR Unreviewed; 373 AA.
AC A0A3Q4G6W9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Probable flap endonuclease 1 homolog {ECO:0000313|Ensembl:ENSNBRP00000004420.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000004420.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000004420.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR AlphaFoldDB; A0A3Q4G6W9; -.
DR STRING; 32507.ENSNBRP00000004420; -.
DR Ensembl; ENSNBRT00000004558.1; ENSNBRP00000004420.1; ENSNBRG00000003505.1.
DR GeneTree; ENSGT00940000155807; -.
DR OMA; CRQTRME; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000003505; Expressed in zone of skin and 6 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09907; H3TH_FEN1-Euk; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF49; FLAP ENDONUCLEASE 1 HOMOLOG-RELATED; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 3..90
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 109..179
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
SQ SEQUENCE 373 AA; 42244 MW; 276DADD3F65CB813 CRC64;
MSKGTFKLLC IHAAVVVLLY STGKVIALDT FIVVNQFRAA TPSLSPLTGL FFRTLTFLEH
GIKPVFVFDG KPPGEKKAVL EKRAQTAGRN YSNQTGTGRS TKECLQLLKY LGVPVIQAPG
DAEALCAQLV REGTVHAVAS EDMDTLPFGA NILIRQLNAK KDSEVIEYSL PKLLEKLQIG
HKEFVDLCIL LGCDYCEKIP GLGPKRALTL IQKHRTIEDV VLHINKKTHP VPNMWKYREA
RKIFLDGPQS SAPELIWTEP NEEALVEFLC HTKRIKEERL RNRMVKFRTM RENKREEREK
EKAEGGGTQT CIKDFFRVTR KRKRLSDVLG RSQTKLLSKV VLTCTTPQEK LIFRCVGNAL
LRDRRHDDHS VSL
//
