ID   A0A3Q4G718_NEOBR        Unreviewed;       650 AA.
AC   A0A3Q4G718;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Sodium/hydrogen exchanger 5-like {ECO:0000313|Ensembl:ENSNBRP00000004136.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000004136.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000004136.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4G718; -.
DR   STRING; 32507.ENSNBRP00000004136; -.
DR   Ensembl; ENSNBRT00000004271.1; ENSNBRP00000004136.1; ENSNBRG00000003277.1.
DR   GeneTree; ENSGT00940000159190; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000003277; Expressed in brain.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF56; SODIUM_HYDROGEN EXCHANGER 5; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 2.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   4: Predicted;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..650
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018569869"
FT   TRANSMEM        103..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        389..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          105..212
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          244..427
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          65..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          526..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..550
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..575
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  72204 MW;  B5D73CBA9ADD0AC2 CRC64;
     MLPLGLMLLL LPAAAADLPG TGAPPLRGPG LGFSPPVPAS PSAPPLLLPQ PGAEYGAPGV
     ALARSAAEEP TGTGEEEDAR EHDHHGGGYR VVQWEWSYVQ TPYIIAIWLL VASVAKILFH
     FSQRFTTVVP ESCMLILLGL VLGGVVLIAN KKQLYQLEPS LFFLFLLPTI VGDAGYFMPA
     RLFFDNLGAI LTYAVVGTLW NAFCTGFSLY AAKLLGFIGQ CCGCRDRAWA QTSKNLQSKP
     VCVLQVLYKV YISFVEVGAE NVQTADYFKG VASFLIVSIG GTMVGLIFAV ILGFITRFTK
     KVRIIEPLLV FLMVYLAYLT AELFSLSAIL SMTFCGIGAN KYVEANISQK SRTTVKYTMK
     TLASIAETII FIFLGISAVD KSKWAWDTGL VSCTLVFIFI FRAVGVVGQT WVLNRFRLVP
     LEKIDQVGGN VLTSARLSLP SMASRASFPE VTNVTNYLRE NGSGVCLDLQ VIDNIPGAKV
     EEDMETHHVL AGNLYKPRRR YQSHYSRHFM PLGEQERQDR EVFQRNMRSR METFKSTRYK
     RHKKERSLKK RRGSDVKEDG SDKPRRNVSW QDKGNANKER ALQPHEHNLK CSQTVQCWTK
     SRLHPRVSVL YVLSAGFSYS SKTFDTLGSF LLLTFSSLMS LGRFRIPLVL
//