ID   A0A3Q4G814_NEOBR        Unreviewed;       915 AA.
AC   A0A3Q4G814;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=ribonuclease III {ECO:0000256|ARBA:ARBA00012177};
DE            EC=3.1.26.3 {ECO:0000256|ARBA:ARBA00012177};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000002398.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000002398.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00000109};
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DR   AlphaFoldDB; A0A3Q4G814; -.
DR   STRING; 32507.ENSNBRP00000002398; -.
DR   Ensembl; ENSNBRT00000002490.1; ENSNBRP00000002398.1; ENSNBRG00000001870.1.
DR   GeneTree; ENSGT00730000111052; -.
DR   OMA; NDGPECR; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000001870; Expressed in blood and 6 other cell types or tissues.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031054; P:pre-miRNA processing; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   CDD; cd19877; DSRM_RNAse_III_meta_like; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 3.30.160.20; -; 1.
DR   Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR044442; RNAse_III_DSRM__animal.
DR   InterPro; IPR036389; RNase_III_sf.
DR   PANTHER; PTHR11207:SF0; RIBONUCLEASE 3; 1.
DR   PANTHER; PTHR11207; RIBONUCLEASE III; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR   SUPFAM; SSF69065; RNase III domain-like; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 2.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00266}.
FT   DOMAIN          504..597
FT                   /note="RNase III"
FT                   /evidence="ECO:0000259|PROSITE:PS50142"
FT   DOMAIN          648..774
FT                   /note="RNase III"
FT                   /evidence="ECO:0000259|PROSITE:PS50142"
FT   DOMAIN          801..875
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   REGION          86..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          895..915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   915 AA;  106683 MW;  E40276D0F04EC9B2 CRC64;
     MDSRRSPERG YRHDDHRRKC FGYGGHGDRH KMEFPGERKD QEEDLLKPAW IRCTHAENYY
     SNDPMDQVVL LSFFFHKANI YKLSPSPHWP PPHVQTDSSD SDCESEGEGT TCSSSSDSEV
     FDVIAEIKRK KAHPDRLHEE LWYNDPGEMN DGPLCKCSAK ARRTGIRHSI YPGEETDRPT
     VIEYDDHEYL FEGFSLFSHT PLTNIPLCRV IRFNIDYTIH FIEEMAPENY CVRGLELFAS
     YLFRDILELY DWNLTGTIPK ARVSGCPRFH FMPRFVRFLP GRTRHRTFFF CHLSPSGGLY
     FLSCLTLPKT LKKLSSSNIH SKLLHSCSVR IDQLDREQFN PDVITFPIIV HFGIRPAQLS
     YAGDPQYQKL WKSYVKLRHL LANSPKVRQI DKQKMTQREE ALQKIRQKNT MRREVTVELS
     SQGFWKTGIR SDVCQHAMML PVLTHHIRYH QCLMHLDKLI AYVFKERCLL QLLLFWGRQI
     PLNFSCHKES AKSSMWSCGG TLINHNERLE FLGDAVVEFL TSVHLYYLFP SLEEGGLATY
     RTAIVQNQHL AMLAKKLELD RFMLYAHGPD LCRESDLRHA MANCFEALMG AVYLEGGLEE
     ARQLFGRLLF NSEDLREVWL NYPPHPLQVQ EPQTDRQLIE TSPVLQKLTQ FEESIGVLFT
     HVRLLARAFT LRTVGFNHLT LGHNQRMEFL GDSIMQLVAT EYLFIHFPDH HEGHLTLLRS
     SLVNNRTQAK VAEELGMQEF AITNDKTKRP VALRTKTLAD LLESFIAALY IDKDLEYVHT
     FMNVCFFPRL KEFILNQDWN DPKSQLQQCC LTLRTEGKEP DIPLYKTLQT VGPSHARIYT
     VAVYFKGERI GCGKGPSIQQ AEMGAAMDAL EKYNFPQMAH QKRFIERKYR QELKEMRRER
     ERQEKETEDS EEYRK
//