ID A0A3Q4G8Z8_NEOBR Unreviewed; 1067 AA.
AC A0A3Q4G8Z8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000002783.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000002783.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q4G8Z8; -.
DR STRING; 32507.ENSNBRP00000002783; -.
DR Ensembl; ENSNBRT00000002882.1; ENSNBRP00000002783.1; ENSNBRG00000002179.1.
DR GeneTree; ENSGT00940000165054; -.
DR OMA; NYWVERF; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000002179; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1067
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018557401"
FT DOMAIN 563..824
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 827..956
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 379..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 119993 MW; EE7190EB6C933761 CRC64;
KSWGWIALPL LWVLWGLCSG STVSLPESLL FVSTLDGNLH AVSKKSGSIK WTLKEDPVLQ
VPTHVAEPAF LPDPNDGSLY SLGGKNNEGL TKLPFTIPEL VQASPCRSSD GILYMGKKQD
LWYVVDLLTG EKQQTLTSSF AEMFCPSSSL LYLGRTEYTI TMYDTKSREL RWNATYSDYA
STLPDDDTKY KMAHFVSNGD GLVVTVDSES GDVQWVQNYN SPVVAMYIWQ REGLRKVAHT
NVAVETLRYL TFMSGEVGRI TQWKYPFPKE KKPKNKFMAT LYVGKYSTSL YASPSLVHDG
VTVVPRGSTF PMLEGPDSQE SEEDKECVIT PSTSVKFNAA LRERNQVNFM RNYLLLIGHH
ETPPEAHTKI LEKFPDSFPR HQANVIPPTT DKKVEEKVND SGMDDGPPSA VPETSIQEPG
TGGRGVRPEA PVDSMLKDMA TIIFSTFLLA GWVAFVITYP KSMHKQQQLQ HQEFQRQMEE
RLEMLQRQQP FPPAEVGMSL TLESDYLEVA RTRSECSDHS SPNVTPRASN HSNLSVSELG
SSANEHEDGE ADSSVVRVGN ITFHPKEVLG HGAEGTIVYK GQFDNRPVAV KRILPECFSF
ADREVQLLRE SDEHPNVIRY FCTERDRQFQ YIAIELCAAS LQEYVERKDF NRHGLEPVML
LQQTMSGLTH LHSLNIVHRD LKPHNILVSM PNAHGRVRAM ISDFGLCKKL AVGRHSFSRR
SGVPGTEGWI APEVLSEDCK DNPTCAVDIF SAGCVFYYVV SQGSHPFGKS LQRQANILLG
SYSLDHLQND KHGDIVARDL IEQMLSMDPH RRPSAESVLK HPFFWSLEKE LQFFQDVSDR
IEKEPLDGPI VRQLERGGRA VVKGDWREHI TVPLQTDLRK FRSYKGGSVR DLLRAMRNKK
HHYRELPAEV QETLGSIPDD FVSYFTSRFP HLLMHTYLAM RTCAPERPFL PYYCSAEQLA
KTQAQLAHHG PQRHNEPCTQ HLPTHTSHSS LPEQVCHTAA TESVPSSAPE PVSSHIPVQT
VQPAEPEPST QTDSHSQTSE STLRQRESNQ PEVTPLTNPP ILDNKPV
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