ID A0A3Q4G9Q7_NEOBR Unreviewed; 506 AA.
AC A0A3Q4G9Q7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Kunitz-type protease inhibitor 1-like {ECO:0000313|Ensembl:ENSNBRP00000005196.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000005196.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000005196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR STRING; 32507.ENSNBRP00000005196; -.
DR Ensembl; ENSNBRT00000005353.1; ENSNBRP00000005196.1; ENSNBRG00000003919.1.
DR GeneTree; ENSGT00940000164935; -.
DR OMA; HRNRFVC; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000003919; Expressed in zone of skin and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd22623; Kunitz_HAI1_1-like; 1.
DR CDD; cd22624; Kunitz_HAI1_2-like; 1.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR46750; KUNITZ-TYPE PROTEASE INHIBITOR 1; 1.
DR PANTHER; PTHR46750:SF1; KUNITZ-TYPE PROTEASE INHIBITOR 1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF07502; MANEC; 1.
DR Pfam; PF18911; PKD_4; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00765; MANEC; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF57362; BPTI-like; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50986; MANSC; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..506
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018689923"
FT TRANSMEM 449..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..114
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 249..299
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 378..428
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 481..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 322..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 329..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 341..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 506 AA; 55869 MW; AE1BEA89B12DD5EB CRC64;
XXXXPFHKPL TSALLVLIVR TVCSTGSDEF RRGHEDFVLY AEDAVKQGAV MLATASFYSE
LECERACCGQ VHCNLALLEP SVPGEENRTC VLFNCVRRNR FACRFVTQSG YKSYVRDAVY
RKYLAAPQKD GEYFQITTAQ TPVICGKKHP PVANAGRDVT IQPGETVMLN GTESVALSGA
KIKDYRWSLE RGDSSVKIEE TNYPDQVQLS NLQTGSYVFK LTVNDSNGKS DDAKVTVLVL
NPQQTSSYCQ APVKVGPCRA KFTRWRYNIT KGVCEMFVFG GCIGNENNFL SEQECLSACR
GVTVSSQRSV TLPAAEVCGS PCGPDQLTCG NGCCLDRSME CDNVKQCSDG SDESQCHQLN
QTLSLLLDID VNKKKAQCTE PPRTGPCRAK FPGWYYDPLD QKCHEFTYGG CDRNENNFPD
DQTCSEYCKE VGGTHKFDMT SLSSSTGSIT LAVILSVAIL SLLAILAYCF LRARKRRTHR
PVNTSPTHEA LSKEETSVYN STTKPM
//
