ID A0A3Q4GGH8_NEOBR Unreviewed; 1009 AA.
AC A0A3Q4GGH8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSNBRP00000002097.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000002097.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000002097.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q4GGH8; -.
DR Ensembl; ENSNBRT00000002181.1; ENSNBRP00000002097.1; ENSNBRG00000001582.1.
DR GeneTree; ENSGT00940000157657; -.
DR OMA; WTQDRDP; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000001582; Expressed in blood and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 126..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..264
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 347..619
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 727..882
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 914..1009
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1009 AA; 111659 MW; 5B8CFC06DDC7F6B3 CRC64;
FCQPLACLFI GSFFFTSKGD DNRRESSAFI NPDMDTEAYY EGKNMALFEE EMDSTPMVSS
FLNKLANYTN LTQGVREHEE AEDGVRRAAV PHMGTFIGVY LPCMQNILGV ILFVRLTWIV
GTAGILGSLA IVSMCCICTL LTAISMSAIA TNGVVPAGGS YYMISRSLGP EFGGAVGLCL
YLGTTFAGSL YILGTIEILL LYIIPPEKVV KETTANDMRI YGTCCLLLMA LVVFVGVKYV
NKLALVFLSC VVLSIMATYA GAIKTAIKPS NFSVCLLGNR TLKNEMFEKC AKTDVELWNL
FCDSPYPNAT CDEYFALNNL TEIQATPGVL GEVINGASLS SKSPLRANND KLKNYVFNDW
ATYFTLLVGI YFPSVTGIMA GSNRSGDLRD AQRSIPIGTI LAILTTSFIY ISCVVLFGAC
IEGVVLRDKF GFSVKTKPVI SILAWPSPWV IVIGSFFSCC GAGLQSLTGA PRLLQAIARD
GIIPFLQVFG HGKANGEPTW ALLLTVGICE IGILIASLDH VAPILSMYVL CSAPPIGDLA
LSSITGMSLC LSLMFISSWI YALVVIVIAG CIYKYIEYKG AVKEWGDGIR GLSLNAARYA
LIRLEEAPLH TKNWRPQLLV LCKLNSELQV THPRLLSFAT QLKAGKGLTI VCSVLEGTYM
TRGDEAKKGE KVPQFVQSFA LIAGLGGMKH NAVLMAWPTG WKQNRDSSAR RNFIETVRET
TSAHQALLVA KNIDHFPANQ ERLKEGTVDV WWIVHDGGLL MLLPFLLSQH KVWRKCKMRI
FTVAQMDDNS IQMKKDLQMF LYQLRLNAVV EVVEMHDSDI SAFTYEKTLV MEQRSQMLKQ
MQLSRTERER EVNGSPNERL RVKITKLIRL YIMSPSVQAQ LIHDRNTASH SAANDKAAGA
TSDRVHMTWT KDKLQNERNK HKENMAVKDM FNMRPSHSNV RRMHTAVKLN DVVVKKSCNS
ELVLLNMPGP PKNKKGDENY MEFLEVLMEG LDRVLLVRGG GREVITIYS
//
